| abstract |
1. The compound of formula I! ! its pharmaceutically acceptable salts, biologically active metabolites, solvates, hydrates, prodrugs, enantiomers or stereoisomers,! where L is a bond or optionally substituted (C1-C3) alkyl; ! R1 is —C (O) —NH-phenyl, —NH — C (O) -furanyl, —NH — S (O) 2-optionally substituted phenyl, —O — optionally substituted (C1-C3) alkyl, —S optionally substituted (C1-C3) alkyl, optionally substituted (C2-C6) alkyl, optionally substituted amino, optionally substituted (C3-C6) cycloalkyl,! - (CH2) (C3) alkyl, tetrahydrobenzofuranyl, furanyl, tetrahydrofuranyl, optionally substituted 2,3-dihydroisoindolyl, optionally substituted imidazolyl, optionally substituted indolyl, optionally substituted isoxazolyl, optionally substituted morpholinyl, optionally substituted naphthyl, optionally O CH2-phenyl, -O-phenyl, -O- optionally substituted phenyl, optionally substituted piperidinyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally optionally substituted pyrrolidinyl, optionally substituted 1,2,3,4-tetrahydroisoquinolinyl, optionally substituted quinolinyl, optionally substituted 5,6,7,8-tetrahydroimidazo [1,2-a] pyrazinyl, optionally substituted pyrrolyl, optionally substituted quinolinyl, optionally substituted thiazolyl or optionally substituted thienyl; ! R2 is Br, Cl, CF3, CN, or —O- (C1-C2) alkyl; ! R3 is optionally substituted - (C3-C8) alkyl, (C4-C5) alkenyl, (C4-C5) alkynyl, optionally substituted - (C3-C6) cycloalkyl, - (C2-C3) alkyl-O-optionally substituted ( C1-C3) alkyl, - (C1- |