http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009126774-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
| filingDate | 2007-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009126774-A |
| titleOfInvention | METHOD FOR PREPARING ANALGETICS |
| abstract | 1. The product of oxymorphone hydrochloride containing less than 10 ppm alpha, beta unsaturated ketones according to HPLC. ! 2. The product according to claim 1, in which the content of alpha, beta unsaturated ketones is less than 5 ppm. ! 3. The product according to claim 1 or 2, in which the ketones include 14-hydroxymorphinone. ! 4. The product according to claim 1 for use as a medicine. ! 5. A pharmaceutical formulation comprising at least one pharmaceutically acceptable excipient and an oxymorphone hydrochloride product according to any one of claims 1 to 3. ! 6. The method of purification of oxymorphone hydrochloride to obtain a product according to claims 1, 2 or 3, comprising the reduction of the starting material of oxymorphone hydrochloride in a strongly acidic aqueous and alcoholic reaction medium, using hydrogen gas at a temperature in the range from 60 to 70 ° C. ! 7. The method according to claim 6, in which the restoration is carried out for a period of at least 20 hours! 8. The method according to claim 6 or 7, in which the restoration is carried out over a period of 1 to 20 hours! 9. The method according to claim 6, in which the reaction medium has a pH of less than 1.! 10. The method according to claim 6, in which the acid is hydrochloric acid. !eleven. The method according to claim 6, in which the temperature is about 65 ° C. ! 12. The method according to claim 6, in which the starting material of oxymorphone hydrochloride is not isolated from the reaction mixture in which it is formed. ! 13. The method according to item 12, in which the starting material of oxymorphone hydrochloride is obtained by heating the free base of oxymorphone in the presence of hydrochloric acid and in an alcohol / water reaction medium. ! 14. The method according to claim 6, in which the starting material of oxymorphone hydrochloride is prepared using the recovery process of 14-hydroxymorphinone. ! 15. The method according to 14, in which the source material 14- |
| priorityDate | 2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.