http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009121641-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-75 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2007-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009121641-A |
| titleOfInvention | Agonistic antibodies to TrkB and their application |
| abstract | 1. An isolated tyrosine kinase receptor B (TrkB) agonist antibody. ! 2. The antibody according to claim 1, where the antibody is a humanized antibody. ! 3. The antibody according to claim 1, where the antibody is a single chain antibody. ! 4. The antibody according to claim 1, where the antibody does not bind to tyrosine kinase receptor A or tyrosine kinase receptor C.! 5. The antibody according to claim 1, where the antibody binds to the ligand binding domain (LBD) of TrkB. ! 6. The antibody according to claim 1, where the antibody competes with brain neurotrophic factor (BDNF) for binding to TrkB. ! 7. The antibody according to claim 1, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 7; and! (II) the variable region of the light chain, including SEQ ID NO: 8. ! 8. The antibody according to claim 7, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 7, SEQ ID NO: 11 and SEQ ID NO: 15; and! (II) the variable region of the light chain, including SEQ ID NO: 8, SEQ ID NO: 12 and SEQ ID NO: 16. ! 9. The antibody of claim 8, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 3; and! (II) the variable region of the light chain, including SEQ ID NO: 4. ! 10. The antibody according to claim 1, where the antibody does not bind to TrkB LBD. ! 11. The antibody according to claim 1, where the antibody does not compete with BDNF for binding to TrkB. ! 12. The antibody according to claim 1, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 5; and! (II) the variable region of the light chain, including SEQ ID NO: 6. ! 13. The antibody according to item 12, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 5, SEQ ID NO: 9 and SEQ ID NO: 13; ! (II) the variable region of the light chain, including SEQ ID NO: 6, SEQ ID NO: 10 and SEQ ID NO: 14. ! 14. The antibody according to item 13, where the antibody contains! (I) the variable region of the heavy chain, including SEQ ID NO: 1; and! (Ii) the variable region of the light flail |
| priorityDate | 2006-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.