| abstract |
1. The compound of formula (I) !! where R1 represents C1-6 alkyl; ! R2 is a phenyl or 5-6 membered heteroaryl ring, each of which may optionally be substituted with one or more substituents independently selected from halogen, cyano, nitro, SH, S (O) 0-2R10, NR11R12, S (O) 2NR13R14, C (O) NR15R16, C (O) 2R17, NR18S (O) 2R19, NR20C (O) R21, NR22C (O) 2R23, NR24C (O) NR25R26, OR27 and C1-6alkyl, where C1-6alkyl may possibly be substituted by one or more substituents independently selected from halogen, hydroxyl, C1-6 alkoxy, NH2, NH (C1-6 alkyl) and N (C1-6 alkyl) 2; ! R3 and R4 together with the nitrogen atom to which they are both attached form a 4-8 membered aliphatic heterocyclic ring, which may optionally contain an additional heteroatom selected from oxygen, sulfur and nitrogen, and which may optionally be substituted with one or more substituents, independently selected from halogen, hydroxyl, C1-6 alkoxy and C1-6 alkyl, where C1-6 alkyl may optionally be substituted with one or more substituents independently selected from halogen and hydroxyl; ! R5 is a group of formula (II) or (III)! or ! where Y is —CH2—, —CH2CH2— or —CH2CH2CH2—, and the ring in group (II) is substituted at 3 or 4 positions; ! a is 1 or 2; ! b is 1 or 2; ! Z represents —CH 2 -; ! R6 is a group of formula (IV)! ! where w is 0 or 1; ! R7 is C1-4 alkylene, optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-6 alkoxy, NH2, NH (C1-6 alkyl) and N (C1-6 alkyl) 2,! when w is 0, then y is 0; when w is 1, then y is 0 or 1; ! Q represents O, C (O), S (O) 0-2, NR9, -CONR9-, -SO2NR9-, -NR9CO-, -NR9SO2-, -OC (O) -, -C (O) O- , -HC = CH- or ethynylene; ! R8 is a cycle� |