| abstract |
1. A composition for topical application in the oral cavity, containing in an orally acceptable carrier a combination of:! (a) one or more of the first active agents having inhibitory activity against at least one of the anti-inflammatory factors of the carrier organism selected from matrix metalloproteinases (MMPs), cyclooxygenases (COX), PGE2, interleukin 1 (IL-1) , IL-1β-converting enzyme (ICE), transforming growth factor β1 (TGF-β1), inducible nitric oxide synthase (iNOS), hyaluronidase, cathepsins, nuclear factor kappa B (NF-κB) and kinase associated with IL-1 receptor (IRAK), and! (b) one or more of the second active agents having inhibitory activity against at least one of the bacterial virulence factors selected from biofilm formation, biofilm adhesion and enzymes selected from gingipaines, METase and cystalysin,! in which the combination is present in an amount that effectively provides increased efficiency for the treatment and prevention of oral conditions mediated by bacteria. ! 2. The composition for topical administration in the oral cavity according to claim 1, in which the first active agent having anti-inflammatory activity is selected from riboflavin, riboflavin phosphate, curcumin, eugenol, dihydroevgenol, thymol, carvacrol, cinnamaldehyde, anthocyanidin, baicalein, tannic acid, quercetin, folic acid, hexamidine, epigallocatechin, epigallocatechin gallate (EGCG), berberine and mixtures thereof. ! 3. An oral composition for topical administration according to claim 1, wherein the second active agent having antibacterial activity is selected from cetyl |