abstract |
1. A compound of formula I or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable and cleavable ester, or an acid or amine addition salt! ! where X1, X2, X3, X4, X5, X6 and X7 are each independently selected from N or CR6,! R6 in each case is independently selected from H, halogen, cyano, OH or optionally substituted (C1-C6 alkyl, C1-C6 alkoxy, aryl C1-C6 alkoxy, heteroaryl C1-C6 alkoxy, C1-C6 alkylamine),! optional substituents on R6 are selected from the groups: C1-C6 alkoxy, OH, halogen, cyano, sulfonyl, C1-C6 alkyl, amino, mercapto, COOH; ! R1 and R2 are each independently selected from H or C1-C6 alkyl, or together they are O; ! R3 is C1-C6 alkyl optionally substituted at any position with one or more R3 'substituents, where R3' is independently selected from COOR11, CON (R12) 2, hydroxyl, amino, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl C1-C6 alkyl, heteroaryl C1- C6 alkyl, C1-C6 alkyl, C1-C6 alkoxy, halogen, cyano, mercapto and sulfonyl,! optional R3 ′ substituents are in turn optionally substituted with one or more substituents: COOR11, CON (R12) 2, hydroxyl, amino, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl C1-C6 alkyl, heteroaryl C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy halogen, cyano, mercapto, sulfonyl; ! two R3 'can form, together with the carbon atoms to which they are attached, a 3-8 membered saturated or unsaturated carbocyclic ring, optionally containing up to 2 ring members selected from CO, CHCOOR11, NR12, O, S, SO, or SO2; ! where R11 independently means H, C1-C6 alkyl or benzyl; and R12 independently means H, OH, C1-C6 alkyl, benzyl or acyl; ! R4 is H, acyl or C1-C6 alkyl; ! or R3 and R4 linked together form a 4, 5, 6 or 7-membered carbocycle |