http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009108272-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2007-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009108272-A |
| titleOfInvention | METHOD FOR CLEANING MONTELUKAST AND ITS AMINOSALES |
| abstract | 1. The method of purification of montelukast, or a pharmaceutically acceptable salt or solvate thereof, including any stereoisomer or a mixture thereof, comprising montelukast in the form of an acid or its solvate, including any stereoisomer or a mixture thereof, is converted to an amine salt selected from the group including salts of L - (+) - threo-2-amino-1-phenyl-1,3-propanediol and L - (+) - α-phenylglycinol, in the presence of a suitable solvent. ! 2. The cleaning method according to claim 1, where the salt of L - (+) - α-phenylglycinol of Montelukast is a solvate selected from the group comprising a solvate of methanol, ethanol and 2-propanol. ! 3. The purification method according to claim 1, where the solvent is selected from the group consisting of simple C2-C8 ether, C4-C8 alkyl ether, C6-C8 aromatic hydrocarbon, C6-C8 non-aromatic hydrocarbon, C2-C5 alcohol and mixtures thereof. ! 4. The cleaning method according to claim 3, where the solvent is selected from the group comprising toluene, ethyl acetate, ethanol, 2-propanol and mixtures thereof. ! 5. The purification method according to claim 1, further comprising a preliminary purification, which includes a series of specific selective extraction of montelukast or its impurities with a solvent and said series of extractions includes at least one washing of the aqueous phase containing the crude montelukast in salt form with an organic solvent , at a pH value from 12.0 to 13.5 and at a temperature of 10 ° C to a temperature 5 ° C below the boiling point of the mixture. ! 6. The cleaning method according to claim 5, where the specified series of solvent extraction includes the following stages:! (a) holding at least. one washing of the aqueous phase containing the crude montelukast in salt form with an organic solvent at a pH of 12.0 to 13.5 and at a temperature of 10 ° C to a temperature of approximately |
| priorityDate | 2006-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.