http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009106169-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C219-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 2007-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009106169-A |
| titleOfInvention | PRODUCTION 3 - [(1R, 2R) -3- (DIMITYLAMINO) -1-Ethyl-2-Methylpropyl] Phenol |
| abstract | 1. A method for producing a compound of formula (VIII), or an acid addition salt thereof, which is characterized by the following steps! a) acylation of a compound of formula (VI), where R is C1-6alkyl, C3-8cycloalkyl, C1-3alkylcarbonyl, tetrahydropyranyl, or C1-3alkyl, substituted phenyl or naphthyl, provided that R - methyl is excluded! ! an acylating agent; ! b) hydrogenolysis of the compound (VII) thus obtained! ! when using a suitable catalyst in a reaction inert solvent in the presence of hydrogen to form product VIII with R1 = R or H:! ! c) optionally removing the protective group R1 of formula VIII in the case of R1 ≠ H and! d) optionally converting the resulting unprotected product into an acid addition salt. ! 2. The method according to claim 1, wherein the acylating agent of step a) is an organic acyl chloride or an organic acid anhydride. ! 3. The method according to claim 2, in which the organic acyl chloride or organic acid anhydride is selected from acetic anhydride, acetyl chloride, trifluoroacetic anhydride, chloroacetic anhydride, chloroacetyl chloride, dichloroacetic anhydride, trichloroacetic anhydride, benzoic acid chloride anhydride, succinyl chloride, ethyl oxalyl chloride, methyloxalyl chloride, Meldrum acid, ethyl chloroformate, methyl chloroformate, or acetylsalicyloyl chloride. ! 4. The method according to claim 3, in which the acid anhydride is trifluoroacetic anhydride. ! 5. The method according to any one of claims 1 to 4, in which the catalyst of step b) is selected from Renney nickel, palladium, palladium on carbon, platinum, platinum on coal, ruthenium or rhodium on carbon, or any |
| priorityDate | 2006-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.