http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009105097-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 |
| filingDate | 2007-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009105097-A |
| titleOfInvention | TETRAHYDROFURO (3,2-b) PYRROL-3-ONE AS CATATEPSIN K INHIBITORS |
| abstract | 1. The compound of formula (I) or a pharmaceutically acceptable salt, hydrate, complex or prodrug thereof! ! where X represents CH or N; ! one of R1 and R2 is H and the other is selected from OR6, SR6, NR6R7, Me, N3, Et, CF3, SOR8 and SO2R8; ! R3 is selected from tert-butyl methyl, sec-butyl, tert-butyl, cyclopentyl and cyclohexyl; ! R4 is optionally substituted C1-8 alkyl or optionally substituted C3-8 cycloalkyl; ! R6 and R7 are each independently selected from C1-8 alkyl and C3-8 cycloalkyl, or R6 and R7 are bonded to the nitrogen atom to which they are attached to form a cyclic group; and! R8 is C1-8 alkyl or C3-8 cycloalkyl. ! 2. The compound according to claim 1, where the specified compound has the formula Ia! ! where X, R1, R2, R3 and R4 have the meanings indicated in claim 1. ! 3. The compound according to claim 1 or 2, where R4 represents an unsubstituted C3-6 cycloalkyl group. ! 4. The compound according to claim 1 or 2, where R4 represents a C1-6 alkyl group optionally substituted by one or more C1-6 alkoxy groups. ! 5. The compound according to claim 1 or 2, where R4 is selected from methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, cyclobutyl and 2-methoxyethyl. ! 6. The compound according to claim 1 or 2, where R3 is cyclopentyl or cyclohexyl. ! 7. The compound according to claim 1 or 2, where R6 and R7 are each independently C1-4 alkyl or C3-6 cycloalkyl. ! 8. The compound according to claim 1 or 2, where R6 and R7 are associated with the formation of an alkylene group! ! where p is 1, 2, 3 or 4.! 9. The compound according to claim 1 or 2, where one of R1 and R2 represents H and the other is selected from Me, Et, CF3, OMe, OEt, OnPr, OiPr, O-cyclopropyl, O-cyclobutyl, SMe, SEt, SnPr , SiPr, S-cyclopropyl, S-cyclobutyl, NMe2, N3, SOMe, SOEt, SOnPr, SOiPr, SO-cyclopropyl, SO-cyclo |
| priorityDate | 2006-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.