http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009103198-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-43 |
| filingDate | 2007-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009103198-A |
| titleOfInvention | NEW PROTEIN CONJUGATES AND METHODS FOR PRODUCING THEM |
| abstract | 1. The conjugated peptide according to formula (I)! ! where Prot is a peptide-derived radical obtained by formally removing a hydrogen atom from the amino group (-NH2) of the indicated peptide,! R1 represents an arylene or heteroarylene optionally substituted with a C1-6 alkyl, halogen, cyano, nitro, hydroxyl, carboxyl or aryl group; ! R2 is a bond or linker, wherein said linker contains a biradical selected from the group consisting of —C (═O) —NH—, —NH—, —O—, —S—, —O — P (O) (OH ) -O-, -OC (= O) -NH-, -NH-C (= O) -NH-, - (CH2) 1-10-, -O- (СН2) 3-NH-C (= O ) -, -С (= O) NH (СН2) 2-30-, - (СН2) 1-30C (= O) NH (СН2) 2-30-, - (CH2) 0-30C (= O) NH - (CH2CH2O) 1-10- (CH2) 1-5-C (= O) -, -C (= O) NH - [(CH2CH2O) 1-10- (CH2) 1-5-C (= O) ] 1-5NH (CH2) 2-30-, -C (= O) -, - (СН2) 1-30-NHC (= O) -, - (СН2) 1-30С (= O) -, -NHC (= O) NH (CH2) 2-30-, - (CH2) 1-30-NHC (= O) NH (CH2) 2-30-, - (CH2) 0-30C (= O) NH (CH2) 2-30-NHC (= O) - (CH2) 0-30-, - (CH2) 0-30C (= O) NH (CH2CH2O) 1-30-CH2CH2NHC (= O) - (CH2) 0-30- or -NH (CH2) 2-30-,! and their combinations! R3 is a property-changing group; ! R4 is hydrogen or C1-6 alkyl; ! R5 is —CH2— or —C (= O) -,! or their pharmaceutically acceptable salts, prodrugs or solvates. ! 2. The compound according to claim 1, where R1 is C6-8-arylene, C12-18-arylene or C5-18-heteroarylene, optionally substituted as described in claim 1. ! 3. The compound according to claim 1, where R2 is a bond, —C (= O) -, —C (= O) —NH— or! ! 4. The compound according to claim 1, where R3 is a linear or branched polyethylene glycol (PEG), poloxamer, polylactic acid, a copolymer of polylactide and glycolide, an oligosaccharide, peptides, proteins, or combinations thereof with possible substitution of acidic or negatively charged functional groups, basic or cationic functional groups or their combinations. ! 5. The compound according to claim 4, where R3 is linear or branched |
| priorityDate | 2006-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 136.