http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009101911-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009101911-A |
| titleOfInvention | Pyridine and Pyrazine Derivatives as Mnk Kinase Inhibitors |
| abstract | 1. The compound of formula I! ! or its pharmaceutically acceptable salt, hydrates, geometric isomers, racemates, tautomers, optical isomers, N-oxides and prodrugs! where X represents N or CH; ! Y and Z are each selected from N or CH; ! A is a bond, -NH- or -N-C1-6alkyl-; ! R1 represents H or NH2; ! Ar is benzofuranyl, indolyl, hydroxyphenyl, thienyl, benzothiophenyl, pyrrolyl, aminocarbonylphenyl or azaindolyl, each of which is unsubstituted or substituted with 1-2 substituents independently selected from hydroxy, halogen atom, —CN, —NO2, C1-6 alkyl, C1 -6 alkoxy, acyl, C1-6 alkylsulfonyl, -C (O) NH2, -NH-C (O) -R7 and arylsulfonyl; ! R1 and R2, each independently, is in the ortho or meta position relative to A and, each independently, is H, a halogen atom, hydroxy, C1-6 alkyl, hydroxy-C1-6 alkyl, carboxy-C1-6 alkyl, C1-6 alkoxy C1-6alkoxy-C1-6alkoxy, di-C1-6alkylamino-C1-6alkoxy or di-C1-6alkylaminocarbonyl-C1-6alkoxy; ! R4 is in the para or meta position relative to A and is —C (O) NR5R6 or —S (O) 2NR5R6; ! R5 is H, C1-6 alkyl or aryl C1-6 alkyl; ! R6 is H, C1-6alkyl, halo-C1-6alkyl, di-C1-6alkamino-C1-6alkyl, mono-C1-6alkylamino-C1-6alkyl, amino-C1-6alkyl, hydroxy-C1-6alkylamino-C1-6alkyl di (hydroxy-C1-6 alkyl) amino-C1-6 alkyl, hydroxy-C1-6 alkyl, dihydroxy-C3-6 alkyl, cycloalkyl, heterocyclyl, heterocyclyl-C1-6 alkyl or heteroaryl-C1-6 alkyl, where heterocyclyl or heteroaryl is unsubstituted or substituted by 1-2 substituents independently selected from C1-6alkyl, C1-6alkyl-OS (O) - or aryl-C1-6alkyl, wherein said C1-6alkyl-OS (O) is attached to the N-atom of the ring; or ! R5 and R6 together with at� |
| priorityDate | 2006-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 272.