http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008152247-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 |
| filingDate | 2007-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008152247-A |
| titleOfInvention | CINNAMOIL-PIPERASIN DERIVATIVES AND THEIR APPLICATION AS PAR-1 ANTAGONISTS |
| abstract | 1. Compounds of the general formula (I):! ! where R1 represents halogen, CN or NO2; ! R2 is hydrogen or halogen; ! n is 1 or 2; ! R3 is phenyl substituted with one or more halogens or C1-C6 alkyls; or cyclohexyl; ! and their therapeutically acceptable salts or solvates. ! 2. The compounds according to claim 1, where R1 is halogen, R2 is hydrogen, n is 1, and R3 is phenyl substituted with one or more halogens or C1-C6 alkyls. ! 3. The compounds according to claim 1, where R1 is a cyano group, R2 is hydrogen, n is 1, and R3 is phenyl substituted with one or more halogens or C1-C6 alkyls. ! 4. The compound according to claim 1, where R1 is halogen, R2 is hydrogen, n is 1, and R3 is cyclohexyl. ! 5. The compound according to claim 1, where R1 is a cyano group, R2 is hydrogen, n is 1, and R3 is cyclohexyl. ! 6. The compound according to claim 1, selected from:! 3- (2-chlorophenyl) -1- [4- (4-fluorobenzyl) piperazin-1-yl] propenone; ! 1- [4- (4-fluorobenzyl) piperazin-1-yl] -3- (2-fluorophenyl) propenone; ! 3- (2-bromophenyl) -1- [4- (4-fluorobenzyl) piperazin-1-yl] propenone; ! 3- (2-chlorophenyl) -1- [4- (4-methylbenzyl) piperazin-1-yl] propenone; ! 3- (2,6-difluorophenyl) -1- [4- (4-fluorobenzyl) piperazin-1-yl] propenone; ! 3- (2,6-difluorophenyl) -1- [4- (4-methylbenzyl) piperazin-1-yl] propenone; ! 3- (2,6-difluorophenyl) -1- [4- (3,4-dimethylbenzyl) piperazin-1-yl] propenone; ! 1- [4- (3,4-difluorobenzyl) piperazin-1-yl] -3- (2,6-difluorophenyl) propenone; ! 1- [4- (4-chlorobenzyl) piperazin-1-yl] -3- (2,6-difluorophenyl) propenone; ! 3- (2,6-difluorophenyl) -1- [4- (3-methylbenzyl) piperazin-1-yl] propenone; ! 1- [4- (3-chlorobenzyl) piperazin-1-yl] -3- (2,6-difluorophenyl) propenone; ! 3- (2,6-difluorophenyl) -1- [4- (2-methylbenzyl) piperazin-1-yl] propenone; ! 3- (2-chlorophenyl) -1- [4- (3-methylbenzyl) piperazin-1-yl] propenone; ! 1- [4- (4-chlorobenzyl) piperazin-1-yl] -3- (2-chlorophenyl) propenone; ! 3- (2-chlorophenyl) -1- [4- (2-fluorobenzyl) piperazin-1-yl] propenone; ! 3- (2-chlorophenyl) -1- [4- (2-methyl |
| priorityDate | 2006-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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