http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008151775-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3348 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-334 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-00 |
| filingDate | 2007-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008151775-A |
| titleOfInvention | METHODS OF SITE SPECIFIC PEGILATION |
| abstract | 1. A method for chemical conjugation of a PEG containing one or more free aldehyde groups with an unoxidized sulfhydryl side chain and a free α-amino group of a D or L-cysteine residue of a molecule, comprising reacting a free aldehyde group of said PEG with an unoxidized sulfhydryl side chain and a free α-amino group the specified cysteine residue with the formation in the product of a 1,3-thiazolidine group, where the specified product has the structure! ! where R1 represents the specified PEG, and R2 represents the specified molecule. ! 2. A method for chemically conjugating a PEG containing one or more free aldehyde groups with an unoxidized sulfhydryl side chain and a free α-amino group of D or L-cysteine residue of a molecule according to claim 1, wherein said method further comprises! interaction in the reaction solution of the free aldehyde group of said PEG with an unoxidized sulfhydryl side chain and the free α-amino group of the indicated cysteine residue to form a 1,3-thiazolidine group in the intermediate product; and! bringing the pH of the reaction solution to a value of about 7, at which the specified intermediate product regroups with the formation of the final product, where the specified intermediate product has the structure! ! and the specified final product has a structure! ! where R1 represents the specified PEG, and R2 represents the specified molecule. ! 3. A method for chemically conjugating a PEG containing one or more free aldehyde groups with an unoxidized sulfhydryl side chain and a free α-amino group D or L-penicyl |
| priorityDate | 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.