http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008151511-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-65 |
| filingDate | 2007-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008151511-A |
| titleOfInvention | STABILIZED INSULIN-LIKE GROWTH POLYPEPTIDES |
| abstract | 1. A polypeptide containing the human IGF-1 precursor protein, in which the cleavage of the E-peptide from IGF-1 by a protease is reduced as a result of modification of the precursor protein, and in which one or more of the following residues in the precursor protein is deleted by fission or modified by mutation: G1, P2, E3, R36 and R37. ! 2. The polypeptide according to claim 1, in which the precursor protein contains an EA peptide. ! 3. The polypeptide according to claim 1, in which the precursor protein contains an Eb peptide. ! 4. The polypeptide according to claim 3, in which the last seven C-terminal amino acids of Eb are deleted as a result of a deletion. ! 5. The polypeptide according to claim 1, in which the precursor protein contains an Ec peptide. ! 6. The polypeptide according to claim 1, in which G1 in the precursor protein is deleted as a result of a deletion or changed as a result of a mutation. ! 7. The polypeptide according to claim 1, in which P2 in the precursor protein is deleted as a result of a deletion or altered as a result of a mutation. ! 8. The polypeptide according to claim 1, in which E3 in the precursor protein is deleted as a result of a deletion or altered as a result of a mutation. ! 9. The polypeptide according to claim 1, in which R36 in the precursor protein is deleted as a result of a deletion or altered as a result of a mutation. ! 10. The polypeptide according to claim 1, in which R36 is replaced by mutation with alanine. ! 11. The polypeptide according to claim 1, in which R37 in the precursor protein is deleted as a result of a deletion or altered as a result of a mutation. ! 12. The polypeptide according to claim 1, in which R37 is replaced by mutation with alanine. ! 13. The polypeptide according to claim 1, additionally containing a consensus sequence of N-linked glycosylation of NXS / T. ! 14. The polypeptide according to claim 3, in which amino acids 93-102 Ea are additionally inserted between amino acids N95 and T96 Eb. ! 15. The polypeptide according to claim 1, to� |
| priorityDate | 2006-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.