http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008151049-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 |
| filingDate | 2007-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008151049-A |
| titleOfInvention | PYROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS |
| abstract | 1. The compound of formula I:! ! where R1 and R2 are independently hydrogen, C1-C7 alkoxy, or halogen; ! CYCL is aryl or cycloalkyl; ! R3 and R4 are independently hydrogen, C1-C7 alkyl, phenyl or naphthyl-C1-C7 -alkyl, halogen-C1-C7 -alkyl, hydroxy-C1-C7 -alkyl, C1-C7-alkoxy- C1-C7-alkyl, amino-C1-C7-alkyl, mono- or di- (C1-C7-alkyl) amino-C1-C7-alkyl, C1-C7-alkanoylamino-C1-C7-alkyl, C1-C7- alkylsulfonylamino-C1-C7-alkyl, halogen, hydroxy, C1-C7-alkoxy, C1-C7-alkoxy-C1-C7-alkoxy, hydroxy-C1-C7-alkoxy, phenyl- or naphthyloxy, phenyl- or naphthyl-C1- C7-alkyloxy, C1-C7-alkanoyloxy, nitro, amino, mono- or di- (C1-C7-alkyl) amino, C1-C7-alkanoylamino, carboxyl, C1-C7-alkoxycarbonyl, phenyl or naphtha tyl-C1-C7-alkoxycarbonyl, carbamoyl, N-mono- or N, N-di- (C1-C7-alkyl-, phenyl-, naphthyl-, phenyl-C1-C7-alkyl- or naphthyl-C1-C7- alkyl-) carbamoyl and N-mono- or N, N-di- (C1-C7-alkyl-, phenyl-, naphthyl-, phenyl-C1-C7-alkyl- or naphthyl-C1-C7-alkyl-) sulfamoyl and cyano; ! R5 is unsubstituted or substituted alkyl, unsubstituted or substituted aryl, substituted or unsubstituted alkenyl, unsubstituted or substituted mono- or bicyclic heterocyclyl, unsubstituted or substituted arylalkyl, unsubstituted or substituted mono- or bicyclic heterocyclylalkylalkyl or ; ! n is 0 or 1; ! R6, R7 and R8 independently of one another are hydrogen, C1-C7-alkyl, phenyl- or naphthyl-C1-C7-alkyl, halogen-C1-C7-alkyl, hydroxy-C1-C7-alkyl, C1-C7- alkoxy-C1-C7-alkyl, amino-C1-C7-alkyl, mono- or di- (C1-C7-alkyl) amino-C1-C7-alkyl, C1-C7-alkanoylamino-C1-C7-alkyl, C1- C7-alkylsulfonyl |
| priorityDate | 2006-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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