http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008149927-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2007-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008149927-A |
| titleOfInvention | DERIVATIVES 1 - [(4- [ENZOIL (METHYL) AMINO] -3- (Phenyl) Butyl] Azetidine FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS |
| abstract | 1. The compound of formula (I) !! where each R1 and R2 is independently selected from hydrogen, methyl, ethyl, or R1 and R2 form a four-, five- or six-membered ring together with amide nitrogen, said ring optionally containing an oxygen atom; ! X represents bromine or chlorine! and their pharmaceutically and pharmacologically acceptable salts and enantiomers of the compounds of formula I and their salts. ! 2. The compound according to claim 1, where R1 is hydrogen. ! 3. The compound according to claim 1, where R1 is methyl. ! 4. The compound according to claim 1, where R1 is ethyl. ! 5. The compound according to any one of claims 1 to 4, where R2 is hydrogen. ! 6. The compound according to any one of claims 1 to 4, where R2 is methyl. ! 7. The compound according to any one of claims 1 to 4, where R2 is ethyl. ! 8. The compound according to claim 1, where R1 and R2 together with amide nitrogen form a morpholine ring. ! 9. The compound according to claim 1, where R1 and R2 together with amide nitrogen form an azetidine ring. ! 10. The compound according to claim 1, where R1 and R2 together with amide nitrogen form a pyrrolidine ring. ! 11. The compound according to claim 1, where R1 and R2 together with amide nitrogen form an isoxazolidine ring. ! 12. The compound according to claim 1, where R1 and R2 together with amide nitrogen form an oxazolidine ring. ! 13. The compound according to any one of claims 1 to 9, where the compound is an (S) enantiomer. ! 14. The compound according to claim 1, which is a maleate 1- {1 - [(3S) -4 - [[3-bromo-5- (trifluoromethyl) benzoyl] (methyl) amino] -3- (4-fluorophenyl) butyl] azetidin-3-yl} piperidin-4-carboxamide. ! 15. The compound according to 14, characterized in that it gives a picture of powder x-ray diffraction, showing substantially the following main peaks with d values:! Initial form of maleate salt Value d (E) Relative intensity 5.48 Very strong 4.92 Very strong 4.77 |
| priorityDate | 2006-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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