http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008146395-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-1384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0607 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0672 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0662 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2007-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008146395-A |
| titleOfInvention | ADULT HUMAN TISSUE STEM CELLS IN LIVER REGENERATION |
| abstract | 1. A method of obtaining hepatic stem cells from non-hepatic stem cells, including! (a) providing stem cells derived from non-hepatic tissues; and ! (b) culturing stem cells on an extracellular matrix comprising at least one fibrillar matrix protein and in a serum-free culture medium comprising hepatic growth factor (HGF),! in which stem cells derived from non-hepatic tissues differentiate into hepatic stem cells. ! 2. The method of claim 1, wherein the non-hepatic tissue is adipose tissue. ! 3. The method of claim 1, wherein the non-hepatic tissue is tissue from an adult mammal. ! 4. The method of claim 1, wherein the at least one fibrillar matrix protein is selected from the group consisting of collagen I and collagen III. ! 5. The method of claim 4, wherein the at least one fibrillar matrix protein is collagen I.! 6. The method of claim 1, wherein the culture medium further comprises oncostatin M, DMSO, or both. ! 7. The method of claim 1, wherein the extracellular matrix further comprises fibronectin, Matrigel, Vitrogen, or combinations thereof. ! 8. The method of claim 1, wherein more than about 70% of the stem cells derived from non-hepatic tissues differentiate into hepatic stem cells. ! 9. The method of claim 1, wherein the stem cells derived from non-hepatic tissues are further obtained from a passage in culture. ! 10. A method of inducing HGF expression from non-hepatic stem cells, including! (a) providing stem cells derived from non-hepatic tissues; and ! (b) culturing stem cells on an extracellular matrix |
| priorityDate | 2006-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.