http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008139632-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-15 |
| filingDate | 2007-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008139632-A |
| titleOfInvention | CHEMICAL DOMAINS OF KUNITZ AND THEIR APPLICATION |
| abstract | 1. Options hTFPI D1 General formula! MHSFCAFKAX10X11GPCX15X16X17X18X19X20X21X22FNIFTRQCEEFIYGGCEGNQNRF! ESLEECKKMCTRD,! containing, in comparison with the natural sequence, at least one mutation at positions X10, X11, X15, X16, X17, X18, X19, X20, X21 and X22, where! X10 represents amino acids D, E, Y, V or S,! X11 is an amino acid D or T,! X15 represents amino acids K or R,! X16 is an amino acid A,! X17 represents amino acids I, R, S or A,! X18 is an amino acid M, I, F or H,! X19 is an amino acid K, I or P,! X20 is an amino acid R,! X21 is an amino acid F or W as well! X22 is an amino acid F or W,! save the peptide sequence! SEQ ID No. 1 (TFPI mut1). ! 2. The peptides of claim 1, further comprising amino acids E and A at the N-terminus. ! 3. The peptides according to claim 1, selected from the group consisting of Seq ID No. 3 (TFPI mut13), Seq ID No. 4 (TFPI mut3), Seq ID No. 5 (TFPI mut4), Seq ID No. 7 (TFPI mut2), Seq ID No. 8 (TFPI mut5), Seq ID No. 9 (TFPI mut6), Seq ID No. 10 (TFPI random). Seq ID No. 11 (TFPI mut7), Seq ID No. 12 (TFPI mut8), Seq ID No. 13 (TFPI mut9), Seq ID No. 14 (TFPI mut10), Seq ID No. 15 (TFPI mut11) and Seq ID No. 16 (TFPI mut12). ! 4. The peptides according to claim 2, selected from the group consisting of Seq No. 17 (TFPI mut15), Seq No. 18 (TFPI mut13EA), Seq No. 19 (TFPI mut3EA), Seq No. 20 (TFPI mut4EA), Seq No. 21 (TFPI mut2EA), Seq No. 22 (TFPI mut5EA), Seq No. 23 (TFPI mut6EA), Seq No. 24 (TFPI randomEA), Seq No. 25 (TFPI mut7EA), Seq No. 26 (TFPI mut8EA), Seq No. 27 (TFPI mut9EA), Seq No. 28 (TFPI mut10EA), Seq No. 29 (TFPI mut11EA), Seq No. 30 (TFPI mut12EA) and Seq No. 31 (TFPI mut15EA). ! 5. DNA encoding one of the peptides according to claims 1-4. ! 6. The vector containing the DNA according to claim 5. ! 7. The microorganism containing DNA according to claim 5. ! 8. The method of producing peptides according to claims 1 to 4 by expression by a microorganism according to claim 5. ! 9. A drug containing one or more peptides according to claims 1 to 4. |
| priorityDate | 2006-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID866 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419556976 |
Total number of triples: 27.