http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008139061-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-22 |
| filingDate | 2007-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008139061-A |
| titleOfInvention | OBTAINING ESLICARBAZEPINE AND RELATED COMPOUNDS ASYMMETRIC HYDROGENIZATION |
| abstract | 1. The method of obtaining the compounds of formula IA or IB! ! where R represents an alkyl, aminoalkyl, haloalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term "alkyl" means a carbon chain, linear or branched, containing from 1 to 18 carbon atoms; the term “halogen” represents fluoro, chloro, bromo or iodo; the term "cycloalkyl" represents a saturated alicyclic group with 3-6 carbon atoms; the term "aryl" represents an unsubstituted phenyl group or phenyl substituted with an alkoxy group, a halogen or a nitro group, the method including asymmetric hydrogenation of a compound of formula II! ! where R has the same meaning as indicated above using a chiral catalyst and a hydrogen source. ! 2. The method according to claim 1, where R is C1-C3 alkyl. ! 3. The method according to claim 2, where R is methyl. ! 4. The method according to claim 1, where the compound of formula IA or IB is respectively the S- or R-enantiomer:! (1) 10-acetoxy-10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (2) 10-benzoyloxy-10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (3) 10- (4-methoxybenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (4) 10- (3-methoxybenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (5) 10- (2-methoxybenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (6) 10- (4-nitrobenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (7) 10- (3-nitrobenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (8) 10- (2-nitrobenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (9) 10- (4-chlorobenzoyloxy) -10,11-dihydro-5H-dibenz (b, f) azepine-5-carboxamide; ! (10) 10- (3-chlorobenzoyloxy) -10,11-dig |
| priorityDate | 2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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