http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008137936-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 |
| filingDate | 2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008137936-A |
| titleOfInvention | TETRAHYDRO-PYRAZOLO [1,5-a] Pyrido-pyrimidines-antagonists of 5-HT6 SEROTONIN RECEPTORS, METHODS FOR PRODUCING AND USING THEM |
| abstract | 1. Substituted 3-sulfonyl-6,7,8,9-tetrahydro-pyrazolo [1,5-a] pyrido [4,3th] pyrimidines of the general formula 1 and substituted 3-sulfonyl-5,6,7,8 Tetrahydro-pyrazolo [1,5-a] pyrido [4,3-d] pyrimidines of the general formula 2 or their pharmaceutically acceptable salts and / or hydrates! ! where Ar is an optionally substituted aryl or optionally substituted heterocyclyl; ! R1 represents a hydrogen atom, optionally substituted lower C1-C3 alkyl, a substituted hydroxy group, a substituted sulfanyl group; ! R2 represents a hydrogen atom or optionally substituted C1-C3 alkyl; ! R3 represents a hydrogen atom, optionally substituted C1-C3 alkyl or tert-butyloxycarbonyl. ! 2. The compounds according to claim 1, which are substituted 3-phenylsulfonyl-6,7,8,9-tetrahydropyrazolo [1,5-a] pyrido [4,3-e] pyrimidines of the general formula 1.1 and substituted 3-phenylsulfonyl-5 , 6,7,8-tetrahydropyrazolo [1,5-a] pyrido [4,3-d] pyrimidines of the general formula 2.1 or their pharmaceutically acceptable salts and / or hydrates! ! where R1, R2 and R3 have the above meaning; R4 represents a hydrogen atom, one or two optionally identical halogen atoms, optionally substituted with C1-C3 hydroxyl alkyl. ! 3. The compounds according to claim 2, which are substituted 2-methylsulfanyl-3-sulfonyl-6,7,8,9-tetrahydro-pyrazolo [1,5-a] pyrido [4,3-e] pyrimidines of the general formula 1.2 and substituted 2-methylsulfanyl-3-sulfonyl-5,6,7,8-tetrahydro-pyrazolo [1,5-a] pyrido [4,3-d] pyrimidines of the general formula 2.2 or their pharmaceutically acceptable salts and / or hydrates! ! where R2, R3 and R4 have the above meaning. ! 4. The compounds according to claim 1, which are 2-methyl-3-phenylsulfonyl-6,7,8,9-tetrahydro-pyrazolo [1,5-a] pyrido [4,3-e] pyrimidine 1.1 (1), 2,5-dimethyl-3-phenylsulfonyl- |
| priorityDate | 2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.