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filingDate 2007-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2010-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2008136316-A
titleOfInvention SODIUM SALT POLYMORPHES N- (4-CHLOR-3METHYL-5-ISOXAZOLYL) -2 {2-METHYL-4, 5- (METHELENDIOXY) Phenylacetyl} THIOPHENE-3-SULFONAMIDE
abstract 1. The compound sodium salt of N- (4-chloro-3-methyl-5-isoxazolyl) -2- [2-methyl-4,5- (methylenedioxy) phenylacetyl] thiophene-3-sulfonamide in the form of polymorph A.! 2. The compound according to claim 1, where the amount of polymorph A is more than about 80%. ! 3. The compound according to claim 1, where the amount of polymorph A is more than approximately 95%. ! 4. The compound according to claim 1, where the amount of polymorph A is more than approximately 99%. ! 5. The compound sodium salt of N- (4-chloro-3-methyl-5-isoxazolyl) -2- [2-methyl-4,5- (methylenedioxy) phenylacetyl] thiophene-3-sulfonamide in the form of a mixture of polymorphs A and B, where the ratio of polymorphs A: B is greater than or equal to approximately 80:20. ! 6. The compound according to claim 5, where the ratio of A: B is greater than or equal to approximately 95: 5. ! 7. The compound according to claim 5, where the ratio of A: B is greater than or equal to approximately 99: 1. ! 8. The compound according to any one of claims 1 to 7, where polymorph A is characterized by peaks in the X-ray powder diffraction pattern (XRD) at approximately 22.38 and 23.38 degrees 2-theta. ! 9. The compound according to any one of claims 1 to 7, where polymorph A is characterized by peaks in the pattern of DRLP at approximately 6.72, 15.96, 22.38, 23.38 and 26.22 degrees 2-theta. ! 10. The compound according to any one of claims 1 to 7, where polymorph A is characterized by a peak in the Raman spectra at approximately 1602.1 cm -1. ! 11. The compound according to any one of claims 1 to 7, where polymorph A is characterized by peaks in the Raman spectra at approximately 1697.4, 1602.1, 1489.8 and 1402.2 cm -1. ! 12. The method of producing polymorph A according to any one of claims 1 to 11, comprising the steps! dissolving the sodium salt of N- (4-chloro-3-methyl-5-isoxazolyl) -2- [2-methyl-4,5- (methylenedioxy) phenylacetyl] thiophene-3-sulfonamide in a warm solvent to obtain a saturated solution; and! cooling this
priorityDate 2006-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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