http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008135690-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2007-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008135690-A |
| titleOfInvention | COMPOUNDS AND COMPOSITIONS AS PROTEINKINASE INHIBITORS |
| abstract | 1. The compound of formula I! ! in which R1 is selected from —NR6R7 and —NR6C (O) R8; where R6 is selected from hydrogen and C1-6alkyl; R7 is selected from hydrogen, C1-6 alkyl, -NR9R10, C6-10 aryl-C0-4 alkyl, C1-10 heteroaryl-C0-4 alkyl, C3-12 cycloalkyl-C0-4 alkyl and C3-8 heterocycloalkyl-C0-4 alkyl; where any aryl, heteroaryl, cycloalkyl or heterocycloalkyl in R7 may be optionally substituted with 1-3 radicals independently selected from C1-6alkyl, C1-6alkoxy, -QNR9R10 and C3-8heterocycloalkyl-C0-4alkyl; where Q is selected from a bond and C1-4 alkylene; R8 is selected from hydrogen and C1-6alkyl; R9 and R10 are independently selected from hydrogen and C1-6alkyl; ! R2 is selected from hydrogen and C1-6 alkyl; ! R3 is selected from hydrogen and C1-6alkyl; ! R4 is selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy,! halogen-substituted C1-6alkyl and halogen-substituted C1-6alkoxy; ! R5 is selected from —C (O) NHR11 and —NHC (O) R11; where R11 is selected from C6-10 aryl and C1-10 heteroaryl; where any aryl or heteroaryl in R11 is optionally substituted with 1-3 radicals independently selected from halogen, C1-6 alkyl, C1-6 alkoxy, halogen-substituted C1-6 alkyl, halogen-substituted C1-6 alkoxy, di-C1-4 alkylamino-C1-6 alkoxy, di C1-4alkylamino-C1-6alkyl (C1-4alkyl) amino,! C1-10 heteroaryl-C0-4 alkyl, C3-8 heterocycloalkyl-C0-4 alkyl and C3-8 heterocycloalkyloxy; where any heteroaryl or heterocycloalkyl substituent in R11 is further optionally substituted with 1 or 2 radicals independently selected from C1-6alkyl and hydroxy-C1-6alkyl; ! X and Y are independently selected from N and CH; and its pharmaceutically acceptable salts, hydrates, solvates and isomers. ! 2. The compound according to claim 1, in which: X represents CH and Y is selected from CH and N; R2 is hydrogen and R3 is hydrogen. ! 3. The compound according to claim 2, in which: R1 is selected from —NHR7 and —NHC (O) R8; where R7 is selected from: hydrogen; amino; m� |
| priorityDate | 2006-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 210.