| abstract |
1. The compound represented by formula (I):! ! or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, wherein:! ring A is selected from the group consisting of aryl and heteroaryl, each of which has the substituents —Y — R1 and —Z — R2, as shown; ! X is selected from the group consisting of -S-, -O-, -S (O) 2-, S (O) -, - (C (R3) 2) m- and -N (R3); ! T represents alkynyl; ! V is selected from the group consisting of hydrogen (H), alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl and N-oxides of said heteroaryl and heterocyclyl, where, when each of said cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl and N- of oxides of said heteroaryl and heterocyclyl contains two radicals at the same or adjacent carbon atoms, these radicals may optionally participate together with the carbon atom (s) to which they are attached, in the formation of a five to eight membered cycloalkyl a cycloalkenyl, aryl, heterocyclyl or heteroaryl ring, wherein each of said cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocyclyl is optionally together with said five to eight membered cycloalkyl, cycloalkenyl, aryl, heterocyclyl or heteroaryl, regardless of whether it is four substituents R10, which may be the same or different; ! Y is selected from the group consisting of covalent bonds,! - (C (R4) 2) n-, -N (R4) -C (O) N (R4) -,! -N (R4) C (O) -,! -N (R4) C (O) N (R4) -, -S (O) 2N (R4) -,! -N (R4) -S (O) 2-, -O-, -S-,! -C (O) -, -S (O) -, and -S (O) 2-; ! Z is selected from the group consisting of covalent bonds, - (C (R4) 2) n-, -N (R4) -, -C (O) N (R4) -, -N (R4) C (O) -, -N (R4) C (O) N (R4) -, -S (O) 2N (R4) -, -N (R4) -S (O) 2-, -O-, -S-, -C ( O) -, -S (O) -, and -S (O) 2-; ! m is an integer from 1 to 3; ! n represents c |