| abstract |
1. The compound of Formula (I):! ! or a pharmaceutically acceptable salt, solvate or ester thereof, in which:! m is 0 or 1, n is 1 or 2, and m + n is 1 or 2; ! the dashed lines () in Formula (I) are single or double bonds, depending on the valence requirements; ! R1 is selected from the group consisting of —C (O) —N (R10) 2, —C (O) —O-alkyl, and —C (O) —R14; ! R2 is selected from the group consisting of H, unsubstituted alkyl, alkyl substituted with one or more U groups, and -alkylene-N (R10) 2; ! or R1 and R2 together with the carbon atoms to which they are attached in the image of Formula (I) form a group Q, as shown in Formula (IA):! ! where Q is selected from the group consisting of:! ,,,,, and; ! Y1 represents —O— or —N (R7) -; ! Y2 represents —O— or —N (R8) -; ! R3, R4, R5 and R6 are each independently selected from the group consisting of H, —O — R9, R11, and —N (R16) 2; ! R7 is selected from the group consisting of H, alkyl, arylalkyl, alkenyl, -alkylene-N (R9) 2, -alkylene-O-R9, -alkylene-R12, -C (O) -R14, - alkylene-C (O ) H, -C (O) -O-R 11 and Boc; ! R8 is selected from the group consisting of H, -alkylene-R12, -C (O) -R17, -S (O2) -R11, -S (O2) -R14, -C (O) -N (R18) 2, R14 and Boc; ! with the proviso that when the group is —N (R18) 2, both R18 groups together with the N atom to which they are bonded form an unsubstituted heterocycloalkyl, heterocycloalkyl substituted with one or more X3 groups, or said substituted or unsubstituted heterocycloalkyl group is fused to aryl, heteroaryl, cycloalkyl or heterocycloalkyl; ! R9 is selected from the group consisting of H, TBS, TIPS, Tf and R11; ! each R10 is independently selected from the group consisting of H, unsubstituted alkyl, alkyl substituted with one or more U groups, -alkylene-R12, -alkylene-R13, -alkylene-R14, -C (O) -R14, -alkylene-O -R9, R14, unsubstituted heterocycloalkyl, heterocycloalkyl substituted with one |