abstract |
1. Compounds of the general formula (I)! ! where Y represents C-R4 and Z represents CH; or ! Y represents C-R4 and Z represents N; or ! Y represents N and Z represents CH; ! R1 represents a 5- or 6-membered ring, respectively, of formulas (II) or (III):! ! ! ! R2 is H, C1-C7 alkyl, C3-C6 cycloalkyl or - (CH2) m-Ra; ! R3 is aryl or heteroaryl, which are optionally substituted with one, two, three or four substituents selected from the group consisting of:! CN, Cl, F, Br, CF3, CHF2, C1-C7 -alkyl, -O-C1-C7 -alkyl, - (CO) -Rb, - (CH2) m-Rc, -NH- (СО) -C1 -C7 -alkyl, -O-CH2F, -O-CHF2, -O-CF3, -S (O) 2-Rd, -NRgRh and heteroaryl, which is optionally substituted with C1-C7-alkyl; ! R4 is H, -OH, -NH2, -NH-C1-C7-alkyl, Cl, F, Br, CF3, CHF2, C1-C7-alkyl or - (CH2) m-Ra; ! R5 represents H, —OH, Cl, F, Br, CN, CF3, CHF2, C1-C7 alkyl, —C3-C6 cycloalkyl, —O- (CO) —C1-C7 alkyl, - (CH2) m-Re or - (CO) -NRiRj; ! R6 is C1-C7-alkyl, -C3-C6-cycloalkyl, C1-C7-alkyl-C3-C6-cycloalkyl, - (CH2) n-O-Rf, C3-C8-alkenyl-O-Rf, - ( CH2) n-NRgRh, -C2-C6 alkenyl-NRgRh or - (CH2) n-Re; ! R7 represents H, Cl, F, CN or C1-C7 alkyl; ! Ra is —O — C1 – C7 alkyl or OH; ! Rb is C1-C7 alkyl, -NRgRh or -O-C1-C7-alkyl; ! Rc is —OH, —NRgRh or NH- (CO) —O — C1-C7 alkyl; ! Rd is C1-C7 alkyl, -NRgRh, NH-C1-C7-alkyl or -N-di (C1-C7-alkyl); ! Re is —OH, —CH 2 F, —CHF 2, —CF 3, CN, C 1 -C 7 alkyl, C 1 -C 7 alkoxy, - (CO) —NRiRj or —O— (CO) —C 1 -C 7 alkyl; ! Rf is C1-C7 alkyl, C3-C8 alkenyl, C3-C6 cycloalkyl, phenyl, benzyl or - (CO) -R '; ! Rg, Rh are independently H, C1-C7 alkyl, C3-C6 cycloalkyl, C3-C8 alkenyl, phenyl, benzyl or - (CO) -R '; or Rg and Rh can also, together with the nitrogen atom to which they are attached, form a 5-7 membered heterocyclic or heteroaryl ring |