http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008131054-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-064 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M11-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A21D2-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-045 |
| filingDate | 2006-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008131054-A |
| titleOfInvention | APPLICATION OF ALPHA-HYDROXYCARBONYL COMPOUNDS AS REDUCING SUBSTANCES |
| abstract | 1. The use of the compounds of formula I! ! in which R1 represents H, aryl, Het or C1-12 alkyl, the latter group of which is optionally substituted with one or more substituents selected from OH, halo and C1-3 alkoxy,! R2 is H or C1-6 alkyl, the last group of which is optionally substituted with one or more OH groups,! aryl is a C6-10 carbocyclic aromatic group which may be substituted with one or more substituents selected from halo, C1-6 alkyl and C1-6 alkoxy! Het is a 4-14 membered heterocyclic group comprising one or more heteroatoms selected from oxygen, nitrogen and / or sulfur, a heterocyclic group which may contain one, two or three rings and may be substituted by one or more substituents selected from halo , C1-6 alkyl and C1-6 alkoxy,! and is characterized in that it is capable of forming a cyclic dimer, formulas Ia! ! in which R1 and R2 are as defined above,! as an activating agent for converting a reduction-activated prodrug into a corresponding active substance. ! 2. The use according to claim 1, wherein the reduction-activated prodrug is one or more compounds selected from:! (a) Metronidazole (2-methyl-5-nitro-1H-imidazole-1-ethanol); ! (b) Chloramphenicol (2,2-dichloro-N - [(αR, βR) -β-hydroxy-α-hydroxymethyl-4-nitrophenethyl] acetamide); ! (c) Nitrofurazone (2 - [(5-nitro-2-furanyl) methylene] hydrazinecarboxamide); ! (d) E09 (3- [5-aziridinyl-4,7-dioxo-3-hydroxymethyl-1-methyl-1H-indol-2-yl] prop-β-ene-α-ol); ! (e) SR-4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide); ! (f) RSU-1069 (1- (1-aziridinyl) -3- (2-nitro-1-imidazolyl) -2-propanol); ! (g) RB-6145 (1- [3- (2-bromoethylamino) -2-hydroxypropyl] -2-n |
| priorityDate | 2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.