http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008131051-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-34 |
| filingDate | 2007-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008131051-A |
| titleOfInvention | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
| abstract | 1. The method of producing sulfonamide-, trifluoroalkyl-substituted alcohol of the structure:! , or ! where R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl, substituted C1-C6 alkyl, CF3, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl and substituted C2-C6 alkynyl; ! R3 is selected from the group consisting of H, C1-C6 alkyl and substituted C1-C6 alkyl; ! R4 is selected from the group consisting of (CF3) n-alkyl, (CF3) n (substituted-alkyl),! (CF3) n-alkylphenyl, (CF3) n-alkyl (substituted phenyl) and (F) n-cycloalkyl; ! n has a value from 1 to 3; ! R5 is selected from the group consisting of H, halogen and CF3; ! W, Y and Z are independently selected from the group consisting of C, CR6 and N, where at least one of W, Y or Z is C; ! X is selected from the group consisting of O, S, SO2, and NR7; ! R6 is selected from the group consisting of H, halogen, C1-C6 alkyl and substituted C1-C6 alkyl; ! R7 is selected from the group consisting of H, C1-C6 alkyl, and C3-C8 cycloalkyl; ! R8, R9, R10, R11 and R12 are independently selected from the group consisting of H, halogen,! C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy and NO2, or! R8 and R9, R9 and R10, R11 and R12 or R10 and R11 are condensed to form:! (1) a carbon saturated ring containing from 3 to 8 carbon atoms,! (2) a carbon unsaturated ring containing from 3 to 8 carbon atoms or! (3) a heterocyclic ring containing in the backbone of said ring from 1 to 3 heteroatoms selected from the group consisting of O, N and S,! where rings (1) to (3) may contain 1-3 substituents, including C1-C6 alkyl or substituted C1-C6 alkyl,! or a pharmaceutically acceptable salt, hydrate or prodrug of said alcohol, comprising reacting a trifluoroalkyl substituted amino alcohol, sulfonyl chloride and a base system |
| priorityDate | 2006-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.