| abstract |
1. An activation inhibitor of VR1, which comprises a 2-aminobenzamide derivative of the general formula (I) or a salt thereof as an active ingredient! ! where is the benzene ring or the pyridine ring,! R3 is the same or different from each other and each represents H, halogen, halogen lower alkyl, cyano, nitro, lower alkyl, -NR4R5, lower alkylene-NR4R5, lower alkylene-NR6-CO2 lower alkyl, -O lower alkyl, -O-halogen lower alkyl, phenyl or thienyl,! m - 1, 2 or 3,! R4 and R5 are the same or different from each other and each represents H or lower alkyl, where R4 and R5 can be combined with an adjacent nitrogen atom to form a monocyclic nitrogen-containing saturated hetero ring, which can be substituted by lower alkyl or a lower alkylene-OH group, ! R6 is H or lower alkyl,! Is a monocyclic hetero ring, cycloalkene or benzene ring,! where the ring represented by A can be substituted with 1-4 groups selected from —OH, —lower alkylene — OH, —lower alkylene-NR4R5, —lower alkylene-CO-NR4R5, halogen, halogen-lower alkyl, lower alkyl and oxo! R1 is lower alkyl, -L-cycloalkyl, L-cycloalkenyl, -L-monocyclic oxygen-containing saturated hetero ring, -L-monocyclic nitrogen-containing saturated hetero-ring, -L- nitrogen-containing hetero-ring, containing a bridging ring, -L-phenyl or -L provided that ring type A, when R1 is lower alkyl, means a ring that forms indoline, tetrahydroquinoline or 3,4-dihydro-2H-1,4-benzoxazine together with the benzene ring with which it is condensed! where the lower alkyl in the group R1 can be substituted by 1-3 groups selected from the groups represented in the group described below |