http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008123398-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745 |
| filingDate | 2006-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008123398-A |
| titleOfInvention | COMPOSITIONS AND METHODS OF HEMOSTASIS MODULATION |
| abstract | 1. A variant of factor X / factor Xa of zymogen / protease that modulates hemostasis. ! 2. The zymogen / protease variant according to claim 1, which is a variant of factor X / factor Xa, encoded by the sequence of SEQ ID NO: 2, in which nucleotides 1684-1695 can encode any amino acid, provided that nucleotides 1684-1686 do not encode Val or Ala. ! 3. The zymogen / protease variant according to claim 1, which contains at least one modification of the sequence of SEQ ID NO: 1, selected from the group consisting of:! a) IIe at position 16 is Leu, Phe, Asp or Gly,! b) Val at position 17 is Leu, Ala or Gly and! c) Asp at position 194 is Asn or Glu. ! 4. The nucleic acid encoding the zymogen / protease variant of claim 3, which optionally encodes an intracellular PACE / furin cleavage site. ! 5. The nucleic acid according to claim 3, having the sequence of SEQ ID NO: 2, in which the nucleotides at positions 1684-1695 encode amino acids selected from the group consisting of Leu-Val-Gly, Gly-Val-Gly, Ile-Ala- Gly, Phe-Val-Gly and Ile-Gly-Gly, wherein said nucleic acid optionally includes nucleotides at positions 2233-2235, which encode an amino acid selected from the group consisting of Asn and Glu. ! 6. A variant of the zymogen / protease encoded by the nucleic acid according to claim 5. ! 7. A pharmaceutical composition comprising a variant of factor Xa according to claim 3 in a biocompatible carrier. ! 8. The nucleic acid according to claim 4, cloned in an expression vector. ! 9. The vector of claim 8, selected from the group consisting of an adenoviral vector, an adenovirus-associated vector, a retroviral vector, a plasmid, and a lentiviral vector. ! 10. A method for treating a hemostasis disorder in a patient in need thereof, comprising administering ter |
| priorityDate | 2005-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.