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filingDate 2006-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2009-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2008119523-A
titleOfInvention BIO-ENGINEERED COLLAGEN CONSTRUCTION, MODIFIED INTESTINAL COLLAGEN LAYER, RECYCLED FABRIC MATRIX AND METHOD FOR RESTORING OR REPLACING DAMAGED TISSUE
abstract 1. Bioengineered collagen construct, characterized in that it includes a layer of purified collagen tissue matrix obtained from the submucosa of the small intestine, wherein said purified collagen tissue matrix is a treated antimicrobial agent. ! 2. The construct according to claim 1, characterized in that it is fenestrated, perforated or made in the form of a mesh. ! 3. The construct according to claim 2, characterized in that it has a cell size ratio of 1: 1.5. ! 4. The construct according to claim 1, wherein the antimicrobial agent is selected from the group consisting of nanocrystalline silver, silver oxide, silver nitrate, silver sulfadiazine, silver imidazolate, Arglaes®, poly (hexamethylene biguanide) hydrochloride, chlorhexidine gluconate, bis- amido polybiguanides, honey, benzalkonium chloride, triclosan idimethyl-octadecyl- (3-trimethoxysilylpropyl) azanium chloride. ! 5. The construct according to claim 1, characterized in that its layer is chemically bonded with 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride. ! 6. A method of repairing or replacing damaged tissue, including implanting a prosthesis into a mammalian patient, characterized in that a prosthesis subjected to controlled biodegradation is reconstructed by adequate replacement by living cells and comprising two or more two overlapping layers of collagen material interconnected, treated with an antimicrobial agent. ! 7. The method according to claim 6, characterized in that a prosthesis is used comprising from two to five sheets of processed intestinal collagen obtained from submucosal �
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