http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008119276-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 |
| filingDate | 2006-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008119276-A |
| titleOfInvention | 3-ALKYL-5- (4-ALKYL-5-OXOTETRAHYDROFURAN-2-IL) PYRROLIDIN-2-ONE DERIVATIVES AS INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF RENIN INHIBITORS |
| abstract | 1. The compound of formula (II)! ! where R3 is C1-C7 alkyl or C3-C8 cycloalkyl, and! R4 is C1-C7 alkyl, C2-C7 alkenyl, C3-C8 cycloalkyl, phenyl or naphthyl (C1-C4) alkyl, each unsubstituted or mono-, di- or trisubstituted by C1-C4 alkyl, O- (C1-C4) alkyl, OH , C1-C4 alkylamino, di (C1-C4 alkyl) amino, halogen and / or trifluoromethyl,! or its salt. ! 2. The compound according to claim 1, where R3 and R4 independently mean branched chain C3-C6 alkyl. ! 3. The compound according to claim 1 or 2, characterized by the following stereochemical structure:! ! 4. The compound according to claim 1 or 2 of the formula! ! 5. The compound of formula (II ')! ! where R3 is C1-C7 alkyl or C3-C8 cycloalkyl, and! R4 is C1-C7 alkyl, C3-C7 alkenyl, C3-C8 cycloalkyl, phenyl or naphthyl (C1-C4) alkyl, each unsubstituted or mono-, di- or trisubstituted by C1-C4 alkyl, O- (C1-C4) alkyl, OH , C1-C4 alkylamino, di (C1-C4 alkyl) amino, halogen and / or trifluoromethyl,! or its salt. ! 6. The compound of claim 5, wherein R3 and R4 are independently branched C3-C6 alkyl. ! 7. The compound according to claim 5 or 6, characterized by the following stereochemical structure:! ! 8. The compound according to claim 5 or 6 of the formula! ! 9. The method of obtaining the compounds of formula (II) according to any one of claims 1 to 4, which consists in the fact that the compound of formula (I ')! ! where R3 and R4 have the meanings indicated for the compound of formula (II), and Aux * means an auxiliary group capable of forming an ester or amide group in the carbonyl function, or its salt, is hydrogenated in the azide group to form the amino group and the lactam ring is closed. ! 10. The method of obtaining the compounds of formula (II) according to any one of claims 1 to 4, which consists in the fact that the compound of formula (I)! ! where R3 and R4 have the meanings indicated for the compound of formula (II), or a salt thereof, are hydrogenated at the azide group to form |
| priorityDate | 2005-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.