http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008116837-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5759 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2006-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008116837-A |
| titleOfInvention | COMPOSITIONS AND METHODS OF STIMULATION OF THE MOTOR FUNCTION OF THE GASTROINTESTINAL TRACT |
| abstract | 1. A method of stimulating the motor function of the gastrointestinal tract in a patient, comprising administering a peptidic analog of ghrelin, a prodrug thereof or a pharmaceutically acceptable salt of said analogue or said prodrug. ! 2. The method according to claim 1, where the specified patient suffers from postoperative intestinal obstruction after surgery on the gastrointestinal tract. ! 3. The method according to claim 1, where the specified patient is simultaneously or pre-administered opioid painkillers. ! 4. The method according to claim 2, where the indicated patient is simultaneously or previously administered opioid painkillers. ! 5. The method according to claim 3, wherein said peptidyl analog of ghrelin comprises a compound of formula (I)! ! where A1 is Gly, Aib, Ala, β-Ala or Acc; ! A2 is Ser, Aib, Act, Ala, Acc, Abu, Ava, Thr or Val; ! A3 is Ser, Ser (C (O) -R4), Asp (O-R8), Asp (NH-R9), Cys (S-R14), Dap (S (O) 2-R10), Dab (S ( O) 2-R11), Glu (O-R6), Glu (NH-R7), Thr, Thr (C (O) -R5) or HN-CH ((CH2) nN (R12R13)) - C (O) ; ! A4 is Phe, Acc, Aic, Cha, 2-Fua, 1-Nal, 2-Nal, 2-Pal, 3-Pal, 4-Pal, hPhe, (X1, X2, X3, X4, X5) Phe, Taz , 2-Thi, 3-Thi, Trp or Tyr; ! A5 is Leu, Abu, Acc, Aib, Ala, Cha Ile, hLeu, Nle, Nva, Phe, Tle or Val; ! A6 is Ser, Abu, Acc, Act, Aib, Ala, Gly, Thr or Val; ! A7 is Pro, Dhp, Dmt, 3-Hyp, 4-Hyp, Inc, Ktp, Oic, Pip, Thz, Tic or is excluded; ! A8 is Glu, Acc, Aib, Arg, Asn, Asp, Dab, Dap, Gln, Lys, Orn, HN-CH ((CH2) n-N (R12R13)) - C (O) or is excluded; ! A9 stands for His, Apc, Aib, Acc, 2-Fua, 2-Pal, 3-Pal, 4-Pal, Taz, 2-Thi, 3-Thi, (X1, X2, X3, X4, X5) Phe or is excluded ; ! A10 is Gln, Acc, Aib, Asn, Asp, Glu or is excluded; ! A11 is Arg, Apc, hArg, Dab, Dap, Lys, Orn, HN-CH ((CH2) n-N (R12R13)) - C (O) or is excluded; ! A12 is Val, Abu, Acc, Aib, Ala, Cha, Nva, Gly, Ile, Leu, Nle, Tle or is excluded; ! A13 is Gln, Acc, Aib, Asn, Asp, Glu or is excluded; ! A14 is Gln, Acc, Aib, Asn, Asp, Glu or is excluded; ! A15 is Arg, hArg, Acc, Aib, Apc, Dab, Dap, Lys, Orn, HN-CH ((CH2) n-N (R12R13)) - C (O) or is excluded; ! A16 is Lys, Acc, Aib, Apc, Arg, hArg, Dab, D |
| priorityDate | 2005-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.