http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008115633-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00 |
| filingDate | 2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008115633-A |
| titleOfInvention | COMPOSITIONS OF PHOSPHODIESTHESIS INHIBITOR TYPE IV |
| abstract | 1. A pharmaceutical composition comprising one or more type IV phosphodiesterase inhibitors ("PDE-IV") and at least one other active component selected from muscarinic receptor antagonists (MRA), β2 agonists, p38 MAP kinase inhibitors and corticosteroids, and one or more pharmaceutically acceptable excipients, wherein the PDE-IV inhibitor is one or more compounds having the structure of Formula Ia or Formula Ib,! where! but. Formula Ia means a compound:! ! and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers or N-oxides, where! when X means oxygen,! R1 is hydrogen, alkyl, heterocyclyl, - (CH2) mC (= O) R3 or (CH2) 1-4OR ', (where m is an integer of 0-2, R3 is alkyl, cycloalkyl, heterocyclyl or optionally substituted with Rp or Rq, where Rp is a heterocyclyl or heteroaryl ring, where the rings are attached to (CH2) mC (= O) via N, and Rq is a heterocyclyl or heteroaryl ring, where the rings are attached to - (CH2) mC (= O) via C, and where R 'is alkyl, alkenyl, alkynyl, saturated or unsaturated cycloalkyl, aryl, heterocyclyl or heteroaryl); ! R2 is (CH2) mC (= O) R3, - (CH2) 1-4OR 'or C (= O) NRxRy {where m, R3 and R' are as defined above, and where Rx and Ry are each independently hydrogen , alkyl, C3-C6 alkenyl, C3-C6 alkynyl, cycloalkyl, carboxy, -S (O) mR5 (where! R5 is hydrogen, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, alkaryl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclyl) , aryl, alkaryl, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl}, or R1 and R2 together form at n |
| priorityDate | 2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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