http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008115034-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2006-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008115034-A |
| titleOfInvention | THIAZOLO [4,5-C] PYRIDINE DERIVATIVES AS MGLUR5 RECEPTOR ANTAGONISTS |
| abstract | 1. The compound of General formula I! ! where R1 represents hydrogen, halogen, cyano, lower alkoxy, lower alkyl or lower alkyl substituted by halogen, cycloalkyl, - (CH2) nO-lower alkyl, -C (O) R ', where R' represents lower alkyl, lower alkoxy or NR2; ! R2 is aryl or 5- or 6-membered heteroaryl; ! R3 is hydrogen, OR, NR2, lower alkyl, cycloalkyl, aryl, heterocycloalkyl, 5- or 6-membered heteroaryl, C (O) NR2, lower alkyl substituted by halogen, or —C (O) R ′, where R ′ represents lower alkyl, lower alkoxy or NR2; ! where aryl, cycloalkyl, heterocycloalkyl or 5- or 6-membered heteroaryl groups for R2 and R3 may be unsubstituted or substituted with halogen, cyano, lower alkyl, lower alkoxy, S (O) 2 -alkyl, S (O) -alkyl, - C (O) R ', where R' is lower alkyl, lower alkoxy or NR2; ! R represents hydrogen or lower alkyl; ! n represents 0.1 or 2; ! and its pharmaceutically acceptable salts. ! 2. The compound of General formula I according to claim 1! ! where R1 represents lower alkyl; ! R2 is phenyl, thiazolyl, pyridinyl, pyrimidinyl or pyrazolyl, where the rings are unsubstituted or substituted with halogen or lower alkyl; ! R3 is hydrogen, phenyl, pyridinyl, pyrimidinyl or isoxazolyl, which may be unsubstituted or substituted with halo or -SO2-lower alkyl. ! 3. The compound of General formula I according to claim 1! ! where R1 represents lower alkyl; ! R2 is phenyl, thiazolyl, pyridinyl or pyrazolyl, wherein the rings are unsubstituted or substituted with halogen or lower alkyl; ! R3 is hydrogen or pyridinyl; and its pharmaceutically acceptable salts. ! 4. The compound of General formula I according to any one of paragraphs. |
| priorityDate | 2005-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.