http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008112679-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate | 2006-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008112679-A |
| titleOfInvention | METHODS OF APPLICATION (+) - 1,4-DIHYDRO-7 - [(3S, 4S) -3-METOXY-4- (METHYLAMINO) -1-PYROLIDINYL] -4-OXO-1- (2-THIAZOLYL) -1, 8-NAFTIRIDIN-3-CARBONIC ACID FOR CANCER TREATMENT |
| abstract | 1. A method for treating leukemia, comprising administering to a person from about 10 to about 90 mg / m2 enantiomerically pure (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1 -pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid, where the leukemia is chronic lymphocytic leukemia, chronic myelocytic leukemia, acute lymphoblastic leukemia or acute myelogenous leukemia. ! 2. The method according to claim 1, where the leukemia is acute lymphoblastic leukemia. ! 3. The method according to claim 2, where acute lymphoblastic leukemia occurs from blast cells of bone marrow, thymus, or lymph nodes. ! 4. The method according to claim 3, where acute lymphoblastic leukemia is a T-cell leukemia. ! 5. The method according to claim 4, where T-cell leukemia is peripheral T-cell leukemia, T-cell lymphoblastic leukemia, cutaneous T-cell leukemia or adult T-cell leukemia. ! 6. The method according to claim 1, where the leukemia is acute myelogenous leukemia. ! 7. The method according to claim 1, where the acute myelogenous leukemia is myeloid leukemia or promyelocytic leukemia. ! 8. The method according to claim 1, where the leukemia is recurrent, refractory or resistant to conventional treatment. ! 9. The method according to claim 1, where the dose is from about 15 to about 80 mg / m2. ! 10. The method according to claim 1, where the dose is from about 50 to about 80 mg / m2, which is administered once a week. ! 11. The method according to claim 10, where the dose is from about 55 to about 75 mg / m2. ! 12. The method according to claim 11, where the dose is approximately 60 mg / m2. ! 13. The method according to claim 11, where the dose is approximately 65 mg / m2. ! 14. The method according to claim 11, where the dose is about 70 mg / m2. ! 15. The method according to claim 11, where the dose is about 75 mg / m2. ! 16. The method according to PP.9-15, where the dose is entered one |
| priorityDate | 2005-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.