http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008110050-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008110050-A |
| titleOfInvention | METHOD FOR MASS PRODUCTION OF THE Fc IMMUNOGLOBULIN AREA WITH REMOTE INITIAL methionine residues |
| abstract | 1. A method of obtaining an immunoglobulin Fc region free of the initial methionine residue on a mass scale, comprising! obtaining a recombinant expression vector comprising a nucleotide sequence encoding a recombinant immunoglobulin Fc region composed of an immunoglobulin Fc region linked at its N-terminus to the hinge region of the immunoglobulin via a peptide bond; ! transforming the prokaryotic cell with a recombinant expression vector to obtain a transformant; ! culturing a transform in order to express the immunoglobulin Fc region as an “inclusion body”; and! isolation and purification of the Fc region of immunoglobulin. ! 2. The method of claim 1, wherein the immunoglobulin Fc region is isolated in monomeric or dimeric form. ! 3. The method according to claim 1, in which the hinge region has two or more consecutive amino acid sequences derived from the hinge region of IgG, IgA, IgM, IgE or IgD. ! 4. The method according to claim 3, in which the hinge region has two or more consecutive amino acid sequences, each of which includes at least one cysteine residue. ! 5. The method according to claim 3, in which IgG is selected from the group consisting of IgG1, IgG2, IgG3 and IgG4. ! 6. The method according to claim 5, in which the hinge region has the amino acid sequence represented by SEQ ID NO: 18, 19, 20, 21, 48, 49, 50, 51, 53, 54, 55, 56, 57, 58, 59 or 60.! 7. The method according to claim 1, wherein the immunoglobulin Fc region is selected from the group consisting of Fc regions of IgG, IgA, IgM, IgE, IgD, and combinations thereof and hybrids. ! 8. The method according to claim 7, in which the immunoglobulin Fc region is an IgG Fc region selected from the group |
| priorityDate | 2005-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457586860 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457586736 |
Total number of triples: 16.