abstract |
1. The compound of formula (I)! ! where R1 is phenyl optionally substituted with halogen, cyano, C1-4 alkyl or C1-4 alkoxy; ! R2 is methyl or ethyl; ! R is hydrogen, or CO2R is (CO2 -) pRp +, where Rp + is a monovalent cation, or two carboxylates can coordinate a divalent cation; ! p is 1 or 2; ! R3 is phenyl optionally substituted with halogen, cyano, C1-4 alkyl, C1-4 alkoxy, CF3 or OCF3; ! when R1 is 2-methyl-3,4-dichlorophenyl and R3 is 4-fluorophenyl, 4-cyanophenyl or 2-methoxyphenyl, then R2 may also be hydrogen; ! or its N-oxide; or a pharmaceutically acceptable salt thereof. ! 2. Salt (2S) -2- [4 - [[4- (3,4-dichloro-2-methyl-phenoxy) -1-piperidyl] methyl] -1-piperidyl] -3-phenylpropionic acid, provided that that it is not a dihydrochloride salt. ! 3. The salt according to claim 2, which is a salt of methanesulfonate or benzenesulfonate. ! 4. The compound according to claim 1, where R2 is methyl. ! 5. The compound according to claim 1, where R1 represents phenyl, possibly substituted by chloro and methyl. ! 6. The compound according to claim 5, where R1 represents 2-methyl-4-chloro-phenyl. ! 7. The compound according to claim 5, where R1 represents 2-methyl-3,4-dichlorophenyl. ! 8. The compound according to any one of claims 1, 4, 5 or 6, where R3 is 4-fluorophenyl. ! 9. The compound according to any one of claims 1, 4, 5, 6 or 7, where R represents hydrogen. ! 10. The compound, which is (2S) -2- (4 - {[4- (4-chloro-2-methylphenoxy) piperidin-1-yl] methyl} piperidin-1-yl) -3- (4-fluorophenyl) -2-methylpropionic acid, or a pharmaceutically acceptable salt thereof. ! 11. Pharmaceutically acceptable salt of (2S) -2- (4 - {[4- (4-chlorop-2-methylphenoxy) piperidin-1-yl] methyl} piperidin-1-yl) -3- (4-fluorine |