http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008105806-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92 |
| filingDate | 2006-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008105806-A |
| titleOfInvention | METHODS FOR IDENTIFICATION OF THERAPEUTIC AGENTS |
| abstract | 1. A method for identifying an agent capable of inhibiting the development of foam cells in atherosclerotic tissues, which includes contacting a macrophage and a test agent and examining whether expression of a phagocytic receptor of class A (SR-A) in said macrophage increases after exposure to macrophage of cholesterol ozonolysis products 4a or 5a in the presence of LDL:! ! ! 2. The method according to claim 1, further comprising quantifying the level of expression of SR-A. ! 3. The method according to claim 2, further comprising comparing a quantitatively determined level of expression of SR-A with a quantitatively determined control level of expression of SR-A. ! 4. The method according to claim 3, characterized in that a quantitatively determined control level of SR-A expression is determined by examining the increase in SR-A expression in a macrophage after exposure to macrophage of cholesterol 4a or 5a ozonolysis products in the presence of LDL and in the absence of exposure to said macrophage test agent. ! 5. The method according to claim 3, characterized in that the quantitatively determined control level of SR-A expression is determined by examining the increase in SR-A expression in the macrophage after exposure to the macrophage of the test agent in the absence of exposure to the macrophage of cholesterol 4a or 5a ozonolysis products in the presence of LDL ! 6. A method for identifying an agent capable of inhibiting the recruitment of macrophages into atherosclerotic tissues, which includes contacting the macrophage and the test agent and examining whether said macrophage migrates toward the source of cholesterol ozonolysis products 4a or 5a:! ! ! 7. The method according to claim 6, additional |
| priorityDate | 2005-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.