http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008104514-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 |
| filingDate | 2006-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008104514-A |
| titleOfInvention | APPLICATION OF ANTAGONISTS OF METABOTROPIC GLUTAMANE RECEPTORS (MGLUR5), ESPECIALLY AFQ056, FOR THE TREATMENT OF THE GASTROINTESTINAL TRACT (GIT), ESPECIALLY GASTRO-FOOD REFLEX (REFLEX) |
| abstract | 1. The use of the compounds of formula (I)! ! in which m is 0 or 1,! n is 0 or 1, and! A stands for hydroxy! X is hydrogen, and! Y is hydrogen, or! And forms a simple connection with X or with Y,! R0 is hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, trifluoromethyl, halogen, cyano, nitro, -COOR1, where R1 is (C1-C4) alkyl or -COR2, where R2 is hydrogen or (C1- C4) alkyl, and! R is —COR3, —COOR3, —CONR4R5 or —SO2R6, where R3 is (C1-C4) alkyl, (C3-C7) cycloalkyl or optionally substituted phenyl, 2-pyridyl or 2-thienyl, R4 and R5 are independently hydrogen or (C1-C4) alkyl and R6 is (C1-C4) alkyl, (C3-C7) cycloalkyl or optionally substituted phenyl! R 'is hydrogen or (C1-C4) alkyl and! R ″ is hydrogen or (C1-C4) alkyl, or! R 'and R' 'together form a -CH2- (CH2) m-! where m denotes 0, 1 or 2, and in this case one of the indices n or m does not denote 0,! provided that R0 is not hydrogen, trifluoromethyl and methoxy, if n is 0, A is hydroxy, X and Y are both hydrogen, R is COOEt and R 'and R' 'together form a group - (CH2) 2-,! in the form of a free base or an acid addition salt, for the manufacture of a pharmaceutical composition for the treatment, prevention and / or delaying the progression of gastrointestinal and urinary tract disorders. ! 2. The use according to claim 1 for the treatment, prevention and / or delay the progression of postoperative disorders. ! 3. The use according to claim 1 for the treatment of disorders of the gastrointestinal tract and urinary tract. ! 4. The use according to claim 3, in which the disorder is selected from the group consisting of gastroesophageal reflux (GPR), belching, functional gastrointestinal upset, function |
| priorityDate | 2005-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.