| abstract |
1. A binding protein containing an antigen binding domain, wherein said binding protein is capable of binding the p40 IL-12 subunit, wherein said antigen binding domain contains at least one CDR containing an amino acid sequence selected from the group consisting of:! CDR-H1. X1-X2-X3-X4-X5-X6-X7 (SEQ ID NO: 55), where! X1 represents D, K, T or S; ! X2 represents Y, S or T; ! X3 represents Y, V, G, W, S or F; ! X4 represents I or M; ! X5 represents H, G, E or V; ! X6 is V or absent; and! X7 is S or absent; ! CDR-H2. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20 (SEQ ID NO: 56), where! X1 represents H, D, G, W, S, Y or R; ! X2 represents I or F; ! X3 represents Y, W, L, S, N, D or G; ! X4 represents W, P, H, T or S; ! X5 represents D, G, E, A or I; ! X6 represents D, G, S, T or N; ! X7 represents D, G, S or P; ! X8 represents K, N, S, E, T or H; ! X9 represents Y, T, P, I or N; ! X10 represents Y, N, T, H, K, S or G; ! X11 represents N or Y; ! X12 represents P, N, A, D or S; ! X13 represents S, E, D or P; ! X14 represents L, K, D, T or Y; ! X15 represents K, F, V, M, R or A; ! X16 represents S, K, Q, P or is absent; ! X17 represents D, G, R or is absent; ! X18 is F or absent; ! X19 represents Q or is absent; and! X20 represents D or is absent; ! CDR-H3. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 (SEQ ID NO: 57), where:! X1 represents R, N or W; ! X2 represents G, T, R, P or H; ! X3 represents I, R, F, Y or Q; ! X4 represents R, V, Y, F or A; ! X5 represents S, N, G, A or R; ! X6 represents A, Y, L, F or M; ! X7 represents M, A, D, L or F; ! X8 represents D |