http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008103280-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4035 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 |
| filingDate | 2006-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008103280-A |
| titleOfInvention | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS |
| abstract | 1. The compound of General formula I! ! wherein ! A is CR1R2 or NR3; ! R1 and R2 are independently C1-4 alkyl; ! R3 is - (CH2) p-Cy1 or C1-6 alkyl optionally substituted with one or more R7; ! m is 1 or 2; ! R4 is —B — R8; ! R5 is hydrogen, C1-4 alkyl, halogen or C1-4 alkoxy; ! R6 may be attached to any available carbon atom of the phenyl ring and is halogen or methyl; ! n is 0 or 1; ! B is -CONR9-, -NR9CO- or -NR9CONR9-; ! R7 is hydroxy, C1-4 alkoxy, halogen, -NR10R10 or phenyl optionally substituted with one or more groups selected from C1-4 alkyl, halogen, C1-4 alkoxy, C1-4 haloalkyl and C1-4 haloalkoxy, and in addition to one and two R7 groups can be attached to the same carbon atom, forming together the group - (CH2) q-; ! R8 is C1-6alkyl or - (CH2) p-Cy2; ! p is 0, 1 or 2; ! q is 2, 3, 4, 5, or 6; ! Cy1 is phenyl, heteroaryl, C3-7cycloalkyl or heterocyclyl, all of which may optionally be substituted with one or more R11; ! Cy2 is phenyl, heteroaryl or C3-7cycloalkyl, all of which may optionally be substituted with one or more R12; ! R9 and R10 are independently hydrogen or C1-4 alkyl; ! R11 is halogen, R13, -OR13 ', -NO2, -CN, -COR13-, CO2R13', -CONR14'R14 ',! -NR14'R14 ', -NR14'COR13', -NR14'CONR14'R14 ', NR14'CO2R13, -NR14'SO2R13, -SR13',! -SOR13, -SO2R13, -SO2NR14'R14, or Cy3; ! R12 is C1-4 alkyl, halo, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy or Cy3; ! R13 is C1-4 alkyl, C1-4 haloalkyl or C1-4 hydroxyalkyl; ! R13 'is hydrogen or R13; ! R14 is C1-4 alkyl or C1-4 hydroxyalkyl; ! R14 'is hydrogen or R14; and! Cy3 is phenyl, heteroaryl, C3-7cycloalkyl or heterocyclyl, all of which may optionally be substituted with one or not |
| priorityDate | 2005-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.