http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008101371-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2006-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008101371-A |
| titleOfInvention | HALOGENIZED PYRAZOLO [1,5-a] PYRIMIDINES (OPTIONS), METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION BASED ON THEM, INTERMEDIATE COMPOUNDS AND METHOD FOR PRODUCING THEM (OPTIONS) |
| abstract | 1. Halogenated pyrazolo [1,5-a] pyrimidines covered by the general structural formula (I):! ! where R represents alkyl (C1-C6); ! R1 is selected from the group consisting of alkyl (C1-C6) and alkynyl (C1-C6); ! X represents a halogen atom; and! Y is selected from the group consisting of -CO- and -SO2-,! and their pharmaceutically acceptable salts. ! 2. Pyrazolo [1,5-a] pyrimidines according to claim 1, in which R means methyl. ! 3. Pyrazolo [1,5-a] pyrimidines according to claim 1, in which R1 means methyl. ! 4. Pyrazolo [1,5-a] pyrimidines according to claim 1, wherein R1 is prop-2-ynyl. ! 5. Pyrazolo [1,5-a] pyrimidines according to claim 1, in which X means fluorine. ! 6. Pyrazolo [1,5-a] pyrimidines according to claim 1, in which X means chlorine. ! 7. Halogenated pyrazolo [1,5-a] pyrimidines selected from the group consisting of:! N- {2-fluoro-5- [3- (thiophen-2-carbonyl) pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-methyl-acetamide; ! N- {2-chloro-5- [3- (thiophen-2-carbonyl) pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-methyl-acetamide; ! N- {2-fluoro-5- [3- (thiophen-2-carbonyl) pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-methylmethanesulfonamide; ! N- {2-chloro-5- [3- (thiophen-2-carbonyl) -pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-methyl-methanesulfonamide and! N- {2-fluoro-5- [3- (thiophen-2-carbonyl) pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-prop-2-ynyl methanesulfonamide; ! and its pharmaceutically acceptable salt. ! 8. The method of obtaining pyrazolo [1,5-a] pyrimidines of the general formula (I) according to claim 1, wherein the intermediate of the formula (II) is reacted:! ! where R, R1, X and Y are as defined for formula (I) a Q means a corresponding leaving group selected from the group consisting of N (dialkyl (C1-C6)), alkylthio (C1-C6) group and alkoxy (C1 -C6) a group with an intermediate of formula (III):! ! and alternatively, the compounds formed during the reaction are reacted in |
| priorityDate | 2005-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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