http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2008100039-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2006-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2008100039-A |
| titleOfInvention | NEW SITE OF PHOSPHORILATION OF MITOGEN-ACTIVATED PROTEINKINASES, MODIFIED PROTEINS AND APPLICATION |
| abstract | 1. MAPK protein selected from! a) a MAPK protein comprising a phosphorylated residue at a phosphorylation site that is different from a site or phosphorylation sites present in the activation segment of said MAPK protein, or a fragment of said protein including said phosphorylated residue, where! said different phosphorylation site is a threonine residue at position 123 (Thr123) p38 of a mouse, α-isoform, or a residue of a positionally equivalent amino acid sensitive to phosphorylation in another MAPK protein, as determined by multiple alignment of amino acid sequences, and! phosphorylation at said different phosphorylation site prevents the activation of said MAPK protein and also its activity towards its substrates; and! b) a MAPK protein comprising a negative charge or a bulk residue at a phosphorylation site or in a region surrounding said phosphorylation site that is different from a site or phosphorylation sites present in the activation segment of said MAPK protein or a fragment of said protein including said phosphorylated residue, where! said different phosphorylation site is a threonine residue at position 123 (Thr123) p38 of a mouse, α-isoform, or a residue of a positionally equivalent amino acid sensitive to phosphorylation in another MAPK protein, as determined by multiple alignment of amino acid sequences, and! the introduction of a negative charge or bulk residue in the specified phosphorylation site or in the region surrounding the specified phosphorylation site |
| priorityDate | 2005-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.