| abstract |
1. A method of modulating the activity of PARP-1 in a mammal, comprising administering to the mammal an effective amount of an organic aromatic compound having from 4 to about 35 carbon atoms, said compound being able to bind to the arginine-34 residue located on the zinc finger -1 of the PARP enzyme -1 and has the ability to donate electrons, so that its π-electron system interacts with a positively charged (cationic) guanidine residue of a specific arginine-34 residue of the “zinc finger” -1 PARP-1, and contains a heterocyclic ring containing a nitrogen atom and not containing a carbonyl residue and a lactam structure, and the substituents do not contain a benzamide or lactam structure. ! 2. The method according to claim 1, characterized in that the organic aromatic compound is selected from the group consisting of compounds of formulas I and II! ! R1, R2, R3 and R4 are independently selected from the group consisting of H, halogen, optionally substituted hydroxy, substituted amine, optionally substituted lower alkyl, optionally substituted phenyl, optionally substituted C4-C10 heteroaryl, and optionally substituted C3-C8 cycloalkyl, or its salt, solvate, isomer, tautomers, metabolite or prodrug,! ! in which R1, R2, R3, R4 and R5 are independently selected from the group consisting of H, halogen, nitro, nitroso, optionally substituted hydroxy, optionally substituted lower alkyl, optionally substituted amine, optionally substituted phenyl, optionally substituted C4-C10 heteroaryl, and optionally substituted C3-C8 cycloalkyl; X is H, N-oxide or optionally substituted alkyl, or a salt thereof, � |