http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007415-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_517501868d65d01ec9e9b8b2e7e9d29a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1991-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfe41290555c7907cf81bb2660d6fccc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e28bf60d0d5637921a1dbc7d40cfd52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9165eb4c4643a949b4e08b63e6c9caf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d79b4e9af749e0d34d2291dfede23c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae183afb64323a4085993c3eed1ca0ca |
| publicationDate | 1994-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007415-C1 |
| titleOfInvention | METHYL - 2,4,6 - TRI - O - ACETYL - 3 - DEOXY - 3,3-C - DICYANO - α - D - GLUCOHEXAPYRANOSIDE SHOWING ANTITUMOR ACTIVITY |
| abstract | FIELD: organic chemistry. SUBSTANCE: product - methyl - 2,4,6 - tri - O - acetyl - 3 - deoxy - 3,3 - C - dicyano - a - D - glucopyranoside, gross- formula is C 15 H 18 O 8 N 2 , m. p. is 118-119 C. Reagent 1: methyl - 2,4,6 - tri - O - acetyl - 3 - deoxy - 3 - C - carbamoyl - 3 - C - cyano - LD 50 - D - glucopyranoside. Reagent 2: thionyl chloride. Reaction conditions: in the presence of dimethylformamide, at 60 C for 1 h. Value α = 197 mg/kg. After a single administration of synthesized substance inhibition of growth of leukosis tumor P-388, melanoma B-16 and Lewis lung carcinoma is observed (by 75; 88 and 82% , respectively). Synthesized compound can be used in medicine. EFFECT: high antitumor activity of the end product. 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110833560-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110833560-B |
| priorityDate | 1991-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.