| abstract |
FIELD: organic chemistry. SUBSTANCE: product - compound of the general formula (1), where Y - -CO- or CH 2 ; A - a simple bond or -O-; p= 1-16, Z - H or -G-O, where G - a simple bond or -CH= CH, and Q - phenyl substituted with C 1 -C 3 -alkoxy-group. Reagent 1: compound of the general formula (2), where Y, A, p and Z - as indicated above. Reagent 2: hydrolyzing agent. Compounds of the general formula (1) inhibit leukotriene B 4 at concentration 10 -6 M by 23-99% . EFFECT: enhanced inhibitory activity of synthesized tricycle compounds. 1 tbl |