http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007147917-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-999 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2006-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007147917-A |
| titleOfInvention | COMPOUNDS SUPPORTING PLURIPOTENTITY OF EMBRYONIC STEM CELLS |
| abstract | 1. A method of maintaining pluripotent stem cells, including the stages of cell growth a) in a basic medium, and b) in the presence of a compound of formula I! ! where R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C6-C10 aryl (C0-C4) alkyl, C5-C10heteroaryl (C0-C4) alkyl, C3-C10 cycloalkyl (C0-C4) alkyl and C3-C10 heterocycloalkyl (C0-C4) alkyl, wherein said alkyl or alkenyl in R1 is optionally substituted with 1 to 3 radicals independently selected from the group consisting of halogen, hydroxy, C1-C6 alkyl and -NR2R3, and any aryl, heteroaryl, cycloalkyl or heterocycloalkyl in the composition R1 is optionally substituted with 1-3 radicals selected from the group consisting of halogen, hydroxy, cyano, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, halogen-substituted alkyl, halogen-substituted alkoxy, -XNR2R3, -XOXNR2R3, -XN-R2S ( 2R3, -XC (O) NR2R3, -XNR2C (O) XOR2, -XNR2C (O) NR2R3, -XNR2XNR2R3, -XC (O) NR2XNR2R3, -XNR2XOR2, -XOR2, -XNR2C (= NR3, O) 0-2R4, -XNR2C (O) R2, -XNR2C (O) XNR2R3, -XNR2C (O) R4, -XC (O) R4, -XR4, -XC (O) OR3 and -XS (O) 0 -2NR2R3, where X is a chemical bond or C1-C4 alkylene, R2 and R3 are independently selected from the group consisting of hydrogen, C1-C6 alkyl and C3-C12c icloalkyl, R4 is C3-C10 heterocycloalkyl optionally substituted with 1 to 3 radicals selected from the group consisting of C1-C6 alkyl, -XNR2R3, -XNR2XNR2R2, -XNR2XOR2 and -XOR2, wherein X, R2 and R3 are as defined above, and in the presence of their pharmaceutically acceptable salts, hydrates, solvates and isomers. ! 2. The method of claim 1, wherein the cells are mammalian cells. ! 3. The method of claim 1, wherein the cells are human embryonic stem cells. ! 4. A compound according to claim 4, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, pyrimidinyl, 3-hydroxy-1-methylpropyl, hydroxyethyl |
| priorityDate | 2005-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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