http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007147355-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007147355-A |
| titleOfInvention | SUBSTITUTED 1,2,3,4-TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLES AND 1,2,3,4,5,6-HEXAHYDRO-AZEPINO [4,3-b] INDOLES - MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, METHODS FOR ITS PRODUCTION AND APPLICATION FOR TREATMENT OF MENTAL DISEASES |
| abstract | 1. A drug substance with neurotropic activity against α-adrenoceptors, dopamine D and serotonin receptors of the central nervous system, General formula 1 in the form of individual optical isomers or racemic mixtures, as well as in the form of free bases (or acids) or in the form of pharmaceutically acceptable salts and / or hydrates, for pharmaceutical compositions and finished dosage forms intended for the treatment and prevention of psychotic diseases! ! where R1 represents an amino group substituent, including a hydrogen atom, optionally substituted C1-C4 alkyl, acyl, alkoxy, heterocyclyl, substituted sulfonyl; ! R2 represents a cyclic system substituent, including a hydrogen atom, a halogen atom, optionally substituted C1-C4 alkyl, CF3, CN, alkoxy, alkoxycarbonyl, carboxyl, heterocyclyl or substituted sulfonyl; ! Ar is optionally substituted aryl or optionally substituted heterocyclyl; ! Alk is optionally substituted C1-C3 alkanediyl, C2-C3 alkenediyl, C2-C4 alkindiyl or an SO2 group; ! n is 1 or 2; ! the solid line with the accompanying dashed line () represent a single or double bond. ! 2. The drug substance according to claim 1, the spectrum of receptor-specific agonistic and / or antagonistic activity of which includes activity against α1A, α1B, α1D, α2A adrenoceptors, dopamine D1, D2L, D2S, D3, D4.2, D4.4 and D4.7 receptors and serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. ! 3. The drug substance according to claim 1, the spectrum of receptor-specific agonistic and / or antagonistic activity of which additionally includes one or more receptors selected |
| priorityDate | 2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.