http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007145989-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-332 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 2006-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007145989-A |
| titleOfInvention | STABLE AND SELECTIVE FORMATION OF TRIPLEXES AND DUPLEXES OF THE HUGSTEN TYPE WITH APPLICATION OF TWISTED INTERCALING NUCLEIC ACIDS (TINA) AND METHOD FOR PRODUCING TINA |
| abstract | 1. A flexible monomer that increases the stacking of the bases, with a common structure! ! where X is a skeletal monomeric unit that can be inserted into the skeleton of an oligonucleotide or oligonucleotide analog, or PNA or PNA analogs, L is a linker, I1 is a first intercalator comprising at least one essentially planar conjugated system, which is capable of stacking together with the nucleic bases of DNA, RNA or their analogues, C is a conjugator and I2 is a second intercalator comprising at least one essentially planar conjugate a system that is capable of stacking together with the nucleic bases of DNA, RNA, or their analogues. ! 2. A flexible monomer that increases the stacking of bases, according to claim 1, where X is able to integrate into the oligonucleotide DNA, RNA, HNA, MNA, ANA, LNA, CAN, INA, CeNA, TNA, (2'-NH) -TNA, ( 3'-NH) -TNA, α-L-ribo-LNA, α-L-xylo-LNA, β-D-ribo-LNA, β-D-xylo-LNA, [3.2.1] -LNA, Bicyclo- DNA, 6-amino-bicyclo-DNA, 5-epi-bicyclo-DNA, α-bicyclo-DNA, tricyclo-DNA, bicyclo [4.3.0] -DNA, bicyclo [3.2.1] -DNA, bicyclo [4.3. 0] amide DNA, β-D-Ribopyranosyl-NA, α-L-Lixopyranosyl-NA, 2'-R-PHK, 2'-OR-PHK, 2'-AE-PHK, α-L-PHK, β -D-PHK, and combinations and modifications thereof. ! 3. The flexible base stacking enhancing monomer according to claim 1, wherein the skeletal monomer unit X includes an alkylene diol, such as ethylene glycol or 1-O-methylene glycerol, which optionally has an alkylene diol partially included in the ring system, such as glycon. ! 4. A flexible monomer that increases the stacking of bases, according to claim 1, where L includes 0-60 atoms. ! 5. A flexible monomer that increases the stacking of bases, according to claim 4, where L includes a chain or ring, or combinations thereof, and / or their substituents. ! 6. � |
| priorityDate | 2005-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.