http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007145595-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 |
| filingDate | 2006-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007145595-A |
| titleOfInvention | METHOD FOR PREPARING TAIGETSIKLIN |
| abstract | 1. A method of producing tigecycline in the form of a reconstitutable powder with a total content of decomposition products of less than 0.9%, including the following operations:! but. reducing and maintaining the oxygen content in water for injection (VDI) of less than 0.5 ppm while maintaining the temperature in the range of about 2 to about 8 ° C; ! b. obtaining a solution of tigecycline in said water obtained as a result of operation “a” with a concentration of about 10 to 50 mg / ml while maintaining the indicated temperature and oxygen content; ! from. filling the vessels with the indicated solution obtained as a result of operation "b"; ! d. lyophilization of the specified solution obtained as a result of operation "c", to obtain from 25 mg to 150 mg of reconstitutable powder in the vessel; ! e. capping said vessel in a nitrogen atmosphere. ! 2. The production method according to claim 1, characterized in that the tigecycline solution obtained as a result of operation "b" has a concentration of about 20 mg / ml. ! 3. The production method according to claim 1 or 2, characterized in that from step "d" 50 to 150 mg of reconstituted powder is placed in the vessel. ! 4. The method according to any one of claims 1 to 2, characterized in that in operation "b" the volume of a solution of tigecycline in water exceeds 80 l. ! 5. The method according to any one of claims 1 to 2, characterized in that in step "a" the oxygen content in the water is 0.5 ppm or less due to nitrogen sparging. ! 6. The method according to any one of claims 1 to 2, characterized in that in step "a" the oxygen content in the water is equal to 0.4 ppm or less due to sparging with nitrogen. ! 7. The method according to any one of claims 1 to 2, characterized in that the content in operation "a" provides oxygen in water equal to 0.1 ppm or less due to sparging with nitrogen. ! 8. Method � |
| priorityDate | 2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.